Imaging of Hypoxia: Tracer Developments

Author:   H.J. Machulla
Publisher:   Springer
Edition:   1999 ed.
Volume:   33
ISBN:  

9780792355298


Pages:   180
Publication Date:   31 January 1999
Format:   Hardback
Availability:   In Print   Availability explained
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Imaging of Hypoxia: Tracer Developments


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Overview

It is a more serious problem than realized in clinical routine work, although a large variety of theoretical and experimental data give clearly proven indications. During incidences and progress of many types of diseases hypoxia may enhance development and progress of the disease and, furthermore, decrease chances of efficient treatment of, e.g., tumors. Hypoxic tumor cells are up to three times more resistant towards radiation therapy than normoxic cells. With a diagnostic tool such as provided by hypoxia tracers suitable for PET and SPECT imaging, the particular tissue situation becomes detectable and, thus, treatable. Although the clinical importance of hypoxia imaging is obviously great, neither the clinical nor the scientific community at an international level has focussed many research activities on the hypoxia problem. As the result of a workshop held by the Section for Radiopharmacy in Tubingen, this book collects observations and findings in order to stimulate the on-going research resulting in important clinical applications. Hypoxia imaging is needed in areas of cardiology, neurology and oncology. Additional applications are to be expected in the field of diabetes, infections and organ transplantation. Therefore, the book addresses those who are basically involved in research in radiochemistry and radiopharmacy as well as those dealing with all biological aspects and facing direct clinical applications.

Full Product Details

Author:   H.J. Machulla
Publisher:   Springer
Imprint:   Springer
Edition:   1999 ed.
Volume:   33
Dimensions:   Width: 15.50cm , Height: 1.20cm , Length: 23.50cm
Weight:   1.030kg
ISBN:  

9780792355298


ISBN 10:   0792355296
Pages:   180
Publication Date:   31 January 1999
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print   Availability explained
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

1 Hypoxia: An Introduction.- 2 The Biology of Technetium Based Hypoxic Tissue Localising Compounds.- 3 Basic Chemistry of 2-Nitroimidazoles (Azomycin Derivates).- 4 Molecular Design Approaches of Hypoxia Tracers.- 5 Syntheses of PET-Tracers for the Determination of Hypoxia.- 6 Quantifying Hypoxia with Radiolabeled Fluoromisonidazole: Pre-Clinical and Clinical Studies.- 7 Detection of Liver Hypoxia by [18F]Fluoromisonidazole and Application in Liver Transplant Disorders.- 8 The Evaluation of Hypoxia in Diabetes.- 9 Radiohalogenated Nitroimidazoles for Single-photon Scintigraphic Imaging of Hypoxic Tissues.

Reviews

'Overall, this text provides a summary of the status of radionuclide imaging of hypoxia. The material is clearly prestented, well referenced and authoritative. The text is concise, and should serve as a reference for investigators interested in pursuing work in this field.' European Journal of Nuclear Medicine 28:5,(2001)


Overall, this text provides a summary of the status of radionuclide imaging of hypoxia. The material is clearly prestented, well referenced and authoritative. The text is concise, and should serve as a reference for investigators interested in pursuing work in this field.' European Journal of Nuclear Medicine 28: 5, (2001)


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