Overview

In vertebrates, the integrin family includes 24 members. As the a-chains were sequenced, some were observed to have an inserted domain similar to the A domain in several matrix and complement proteins. This inserted ligand binding domain is interactive and was called the I domain in integrins. More recently structural data have shown that an integrin b-chain also contains an I domain. Nine of the currently known 18 a-chains contain an I domain. This book systematically goes through the contemporary knowledge about these integrins, including the newest additions to the integrin family, the collagen-binding a10b1 and a11b1 integrins. The book discusses ligand binding, signalling properties, knock-out phenotypes and possible involvement in disease. It comprehensively reviews contemporary knowledge about I domains in integrins and should serve as a useful reference book for scientists in this field.

Full Product Details

Author:   Donald Gullberg
Publisher:   Springer Science+Business Media
Imprint:   Kluwer Academic/Plenum Publishers
Edition:   2003 ed.
Dimensions:   Width: 15.20cm , Height: 1.90cm , Length: 22.90cm
Weight:   0.485kg
ISBN:  

9780306478369

ISBN 10:   0306478366
Pages:   186
Publication Date:   31 July 2003
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Preface. 1. Evolution of Integrin I-Domains; M.S. Johnson, D. Tuckwell. 2. Integrin alpha1beta1; H. Gardner. 3. Function of alpha2beta1 Integrin; M.M. Zutter, S.A. Santoro. 4. Structure Distribution and Function of alpha10beta1 Integrin; E. Lundgren-Akerlund, M. Schneller. 5. Structure and Function of alpha11beta1 Integrin; D. Gullberg, S.N. Popova, C.-F. Tiger. 6. Structure and Activation of beta2-Integrins; C.G. Gahmberg, S. Fagerholm. 7. Integrin alphaEbeta7: Molecular Features and Functional Significance in the Immune System; P.J. Kilshaw, J.M.G. Higgins. 8. Structural Aspects of Integrins; R.C. Liddington. 9. Integrin Recognition Motifs in Collagens; R.W. Farndale. 10. Cellular Signaling by Collagen-Binding Integrins; J. Heino. 11. Collagen-Binding Integrins and Disease; B. Eckes, B. Nieswandt, T. Krieg. 12. Integrins in Immune and Inflammatory Disease; A.R. de Fougerolles. Index.

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