Overview

Hyponatremia and 40 Years of Controversy: Looking Back and Moving Forward traces and probes the prolonged, contentious debate surrounding the treatment of sever hyponatremia, a low-sodium concentration in the blood that can result in severe brain damage if managed incorrectly. A mix of memoir and science, the book explains how slow correction of hyponatremia became accepted and how consensus was disrupted by assertions that caution was unnecessary and harmful. It scrutinizes the controversy, offers an approach to management, and unpacks research limitations – reminding us that what is believed true today may change tomorrow. Hyponatremia and 40 Years of Controversy: Looking Back and Moving Forward is a vital resource for both experienced medical specialists and novice trainees. It explains the physiology of how hyponatremia happens and how it hurts. By offering historical insights, scientific rigor, and practical guidance, this book promises to enhance clinical decision making, foster new research, and improve outcomes in patients with hyponatremia.

Full Product Details

Author:   Richard H. Sterns, MD (University of Rochester School of Medicine and Dentistry and Rochester General Hospital, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   0.450kg
ISBN:  

9780443416101

ISBN 10:   0443416109
Pages:   300
Publication Date:   01 December 2025
Audience:   Professional and scholarly ,  College/higher education ,  Professional & Vocational ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Forthcoming
Availability:   Not yet available  
This item is yet to be released. You can pre-order this item and we will dispatch it to you upon its release.

Table of Contents

PART ONE: Salt, Science, Serendipity, and Strife Introduction to Part One: Memoir of an Accidental Expert 1. From central pontine myelinolysis (CPM) to osmotic demyelination syndrome (ODS): what’s in a name? 2. What’s rapid correction? 3. Osmotic stress and demyelination: what’s the connection? 4. Hyponatremic Encephalopathy: Age, Sex, Hormones and Oxygen 5. Speed Limits and How to Obey Them PART TWO: A Grain of Salt Introduction to Part Two: Turning points Role reversal: an expert challenged 6. New Evidence: Rare or just not well done? 7. The Court’s in Session 8. Primum non nocere PART THREE: A Clinician’s Guide to Hyponatremia Management 9. A toolbox for managing hyponatremia 10. Case studies 11. Nutrition, fluid intake, lifestyle and hyponatremia 12. Beyond the controversy: the future of hyponatremia management

Reviews

Author Information

Richard H. Sterns is a nephrologist, a Professor Emeritus at the University of Rochester School of Medicine and Dentistry, a former Chief of Medicine at Rochester General Hospital, and an Editor-in-Chief for Fluid and Electrolytes for UpToDate. Dr. Sterns is a graduate of Stanford University who completed his medical degree at the University of Pennsylvania; internal medicine training at the University of California San Francisco Medical Center and Albert Einstein School of Medicine; and his nephrology fellowship at the University of Pennsylvania. Dr. Sterns introduced the term “Osmotic Demyelination Syndrome” (a serious neurological complication caused by overly rapid correction of hyponatremia) in 1986 and has published extensively on the subject of hyponatremia.

Tab Content 6

Author Website:  

Countries Available

All regions