Overview

In this volume, Professor Bernard Testa and Dr Joachim Mayer discuss the molecular and biochemical aspects of metabolic reactions of hydrolysis and hydration. While an encyclopaedic treatment is avoided, the covered topics include biochemical properties of the enzymes/isozymes, drug-enzyme interactions, the various chemical reactions catalyzed by the enzyme(s), reaction mechanisms and catalytic cycles, regio- and stereoselectivities, structure-metabolism relationships, molecular aspects of toxication and detoxication, as well as enzyme inhibition. The classification of matters is based mainly on the types of target groups and compounds being transformed, with carefully selected examples illustrating the reactions under discussion. Such a treatment has heuristic value since it renders the reader capable of educated guesses on the metabolism of other or novel drugs.

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9783906390253

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This book provides an outstanding and comprehensive review of metabolic reactions catalyzed by hydrolytic enzymes...and their role in the biotransformation of xenobiotic substances. (Journal of the American Chemical Society, December 22, 2004) For the first time, the metabolic reactions of hydrolysis...of drugs, prodrugs, and many other xenobiotics are tightly and comprehensively organized under a single cover. (Pharmaceutical Research, June 2004)

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