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Full Product Details

Author:   Andrew P. Grieve
Publisher:   Taylor & Francis Ltd
Imprint:   Chapman & Hall/CRC
Weight:   0.460kg
ISBN:  

9781032111292

ISBN 10:   1032111291
Pages:   188
Publication Date:   20 June 2022
Audience:   College/higher education ,  General/trade ,  Tertiary & Higher Education ,  General
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

List of Figures..........................................................................................................xi List of Tables......................................................................................................... xiii Preface......................................................................................................................xv Acknowledgements..............................................................................................xix Author.....................................................................................................................xxi List of Acronyms................................................................................................ xxiii 1. Introduction......................................................................................................1 2. All Power Is Conditional Unless It’s Absolute..........................................9 3. Assurance........................................................................................................33 4. Average Power in Non-Normal Settings...................................................59 5. Bayesian Power..............................................................................................75 6. Prior Distributions of Power and Sample Size........................................87 7. Interim Predictions......................................................................................101 8. Case Studies in Simulation........................................................................ 113 9. Decision Criteria in Proof-of-Concept Trials..........................................127 10. Surety and Assurance in Estimation........................................................149 References.............................................................................................................161 Appendix 1 Evaluation of a Double Normal Integral...................................171 Appendix 2 Besag’s Candidate Formula.........................................................173 Index......................................................................................................................175

Reviews

"""This is a graduate level/practitioner book in ten chapters covering expected, average and predicted power, assurance and Bayesian power followed by a shift in focus to priors, interim predictions and multiple decision criteria. The final chapter looks at surety. The book is logically laid out, with formulae for the normal theory case, some examples, and helpful figures."" ~Maia Lesosky, ISCB Book Reviews"

Author Information

Andrew P. Grieve is a Statistical Research Fellow in the Centre of Excellence in Statistical Innovation at UCB Pharma. He is a former Chair of PSI (Statisticians in the Pharmaceutical Industry) and a past-President of the Royal Statistical Society. He has over 45 years of experience as a biostatistician working in the pharmaceutical industry and academia and has been active in most areas of pharmaceutical R&D in which statistical methods and statisticians are intimately involved, including drug discovery, pre-clinical toxicology, pharmaceutical development, pharmacokinetics and pharmacodynamics, phase I–IV of clinical development, manufacturing, health economics and clinical operations.

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