Overview
It is now almost a decade since the identification of the Huntington's Disease gene and its mutation, during which time, major advances in our understanding of this disorder have been achieved. Since publication of the first two editions of this book, there have been considerable insights into how the mutation leads to the molecular pathology, neuropathology and clinical symptoms of Huntington's Disease, and experimental tools are now in place to take this research further towards new therapeutic approaches. As a result of these major advances, this well-established series of books has required radical updating. An international group of researchers and clinicians with specialist interests in HD has been commissioned to document the recent advances in our understanding of this disease. Developments in the fields of structural biology, cell biology, neurochemistry and neuropathology, with full coverage of transgenic animal models, are discussed in detail. The clinical sections cover genetic, neurological and psychiatric aspects as well as new developments in therapy. This book will continue to provide an invaluable source of information for clinicians and scientists involved with Huntington's Disease, including geneticists, psychiatrists and neurologists, and basic science research workers in genetics and neurobiology.
Full Product Details
Author: Gillian Bates (Professor of Neurogenetics, Division of Medical and Molecular Genetics, GKT School of Medicine, King's College, Guy's Hospital, London, UK) ,
Peter Harper (Professor of Medical Genetics and Consultant Physician, Institute of Medical Genetics, University Hospital of Wales College of Medicine, Heath Park, Cardiff, UK) ,
Lesley Jones (Senior Lecturer in Neuropsychiatric Genetics, Institute of Medical Genetics, and Department of Psychological Medicine, University of Wales College of Medicine, Health Park, Cardiff, UK)
Publisher: Oxford University Press
Imprint: Oxford University Press
Edition: 3rd Revised edition
Volume: 45
Dimensions:
Width: 17.50cm
, Height: 3.50cm
, Length: 24.80cm
Weight: 1.230kg
ISBN: 9780198510604
ISBN 10: 0198510608
Pages: 574
Publication Date: 03 October 2002
Audience:
Professional and scholarly
,
Professional & Vocational
Format: Hardback
Publisher's Status: Active
Availability: To order
Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us.
Reviews
It should be an essential part of the library of all neurology and genetic departments ... it is so clearly written that it can be recommended to families affected by HD who have a desire to know as much as possible about the condition. Journal of Neuromuscular Disorders ... the third edition of Huntington's Disease is a goldmine ... Everyone who studies HD should own and read this book, and - to the extent that HD continues to provide a model and a benchmark - so should anyone interested in human genetic disorders Human Genetics, 114
