Human T-cell Leukemia Virus

Author:   P. K. Vogt
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Volume:   115
ISBN:  

9783540139638


Pages:   276
Publication Date:   01 January 1985
Format:   Hardback
Availability:   Out of stock   Availability explained
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Human T-cell Leukemia Virus


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Overview

characteristic features in common with the genome of other retroviruses: long terminal repeats (L TR), and coding regions for internal proteins (gag), for re- verse transcriptase (pol), and for glycosylated virion surface proteins (env) , ar- ranged in the sequence gag, pol, env from the 5' to the 3' end of the genome. However, the HTL V genome also contains some specific features not shared with all other retroviruses: the LTR regions are unusually long (745 base pairs, with 298 base pairs constituting the R region), but unlike the long L TRs of mouse mammary tumor viruses, they do not contain open reading frames. A stretch of noncoding sequences separates the gag and the pol genes. Most interestingly, the HTLV genome contains a region between the 3' end of the env gene and the L TR, called the pX region, that encompasses four open reading frames. Leukemic T cells freshly obtained from patients contain the HTL V provirus but usually do not express it. However, once established in culture, these cells produce viral proteins and release type C particles. Likewise, T cells infected and transformed by HTL V in vitro synthesize virus. Such producing cell lines have been widely used in seroepidemiological surveys and continue to be of importance for detailed studies of viral proteins and nucleic acids.

Full Product Details

Author:   P. K. Vogt
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Volume:   115
Weight:   0.630kg
ISBN:  

9783540139638


ISBN 10:   354013963
Pages:   276
Publication Date:   01 January 1985
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock   Availability explained
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

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