Overview

This book provides an integrated review of the human ocular microbiome. It documents the discovery of ocular surface microbes by the conventional cultivable method and next generation sequencing technologies in both healthy and diseased (keratitis, uveitis, endophthalmitis, blepharitis, conjunctivitis etc.) eyes. The book further discusses the confounding factors that influence the microbiome, mycobiome and virome. The chapters cover niche-specificity with reference to skin, eyelid- margin, hands etc. It highlights the concept of core genera, dysbiosis and discriminating genera and covers the functional relevance of the dysbiotic microbiome, mycobiome and virome with respect to ocular diseases. The book includes topics on the relevance of molecular mechanisms, including quorum-sensing and mucin metabolism to ocular disorders, such as dry eye; and, microbiome-based therapies for treating of ocular disorders like vernal keratoconjunctivitis.  The book is essential for microbiologists studying the human eye, ophthalmologists treating eye infection and trauma. It also caters to students of medical microbiology and medicine.

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9789811917561

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Dr. S Shivaji, Director Emeritus and Senior Scientist at the Brien Holden Eye Research Centre at LVPEI, Hyderabad, was the Director of BHERC till 2020. His research focuses on the connection between gut and ocular microbiomes with eye diseases. Earlier, at the CCMB, he explored the microbial diversity of Antarctica, Arctic, Himalayas, and Stratosphere. He is a fellow of National Academy of Sciences, Indian Academy of Sciences, Telangana Akademi of Sciences and Association of Microbiologists of India. He is a recipient of National Antarctic Award, National Polar Sciences and Cryosphere Award, E K Janaki Ammal Award, and others. He is ranked among the top 2% of scientists in the world and has published > 350 research papers and 2 books.

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