Overview

This second edition focuses on the study of human interphase chromosomes and its relation to health and disease. Orchestrated organization and behavior of the human genome in interphase nuclei at chromosomal level has been repeatedly shown to play a significant role in almost all basic biological processes involved in the processing and inheritance of genetic information within and between species. Accordingly, post-genomic bioscience appeals to basic and applied studies of interphase nuclei genetics and genomics with special attention to interphase chromosome behavior in health and disease. Additionally, elucidating the role of interphase chromosome behavior during development, chromosome/DNA replication, DNA reparation opens new horizons for basic and applied bioscience   Studies of interphase nuclei have an appreciable impact on different areas of biomedical sciences such as cell biology, neurobiology, cancer research, developmental biology, epigenetics, cytogenetics, and medical genetics, as a whole. Moreover, development of innovative and emergent technologies to analyze interphase nuclei are closely associated with application of these techniques in diagnostic and research practices to solve reproductive problems (including infertility and spontaneous abortions), to investigate congenital malformations (including those produced by aneuploidy and other chromosome abnormalities); genetic diseases (including cardiac, immune, neurological and psychiatric diseases), and cancer. This second edition serves as a source of updated valuable information and promising ideas for a wide audience of professionals in biomedicine including researchers, scientists, and healthcare professionals in human genetics, cytogenetics, and developmental biology.

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9783030625344

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Ivan Y Iourov (PhD, Dr. Sci, professor of the Russian Academy of Sciences) is a head of prof. Yurov’s lab of Molecular Genetics and Cytogenomics of the Brain in Mental Health Research Center (Moscow, Russia) and professor (medical genetics) in Russian Medical Academy of Continuous Professional Education (Moscow, Russia). Prof. Iourov is the Editor-in-Chief of Molecular Cytogenetics (BMC/Springer/Nature). His research is focused on cytogenomic and systems biology studies of the human brain. The research interests encompass chromosome research, genomics, neuroscience, neuropsychiatry, bioinformatics, and system theory. He has (co-)authored >400 publications.   Svetlana G. Vorsanova (PhD, Dr. Sci, professor) is a head of laboratory of molecular cytogenetics of neuropsychiatric diseases om Veltischev Research and Clinical Institute for Pediatrics of Pirogov’s Russian National Research Medical University. The research of her lab is dedicated to molecular cytogenet^600 publications.   Yuri B. Yurov (PhD, Dr. Sci, professor; 1951-2017) was a pioneer of interphase molecular cytogenetics. He was the founding editor of Molecular Cytogenetics (BMC/Springer/Nature). He has (co-)authored >650 publications, including descriptions of groundbreaking studies in molecular cytogenetics of the human brain.

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