Overview

This book addresses a wide range of basic and clinical issues in the physiology and pharmacology of growth hormone. The volume is organized like a textbook. It begins with factors contributing to GH gene expression, the functional relationships of the GH receptor, molecular biological analysis of the GH-GH receptor complex and proceeds to describe the insulin-like growth factor axis. Transgenic models are discussed for analysis of discrete effects. These discussions provide a bridge to clinically oriented discussions of growth abnormalities in GH deficient children, GH insensitivity due to deficiency of the GH receptor, and the concept of aging as a GH GF-I deficiency state. Discussions also include the immune system as a source and a responder to GH, GHRH, IGF-I and the effects of GH excess.

Full Product Details

Author:   Kathleen T. Shiverick ,  Arlan L. Rosenbloom (Children's Medical Service Center, Gainesville, FL, USA)
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Volume:   18
Dimensions:   Width: 15.60cm , Height: 1.80cm , Length: 23.40cm
Weight:   0.512kg
ISBN:  

9780849383847

ISBN 10:   0849383846
Pages:   192
Publication Date:   09 March 1995
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

Human Growth Hormone Gene Expression in Pituitary and Placenta, N.E. Cooke and S.A. Liebhaber Growth Hormone-Prolactin Receptor Gene Family, P.A. Kelly, M. Nagano, A. Sotiropoulos, J.-J. Lebrun, P. Touraine, L. Goujon, H. Dinerstein, F. Ferrag, H. Buteau, A. Pezet, N. Esposito, J. Finidori, M.-C. Postel-Vinay, and M. Edery Rational Design of Potent Antagonists to the Human Growth Hormone Receptor, A.M. DeVos, M.H. Ultsch, A.A. Kossiakoff, G. Fuh, B.C. Cunningham, and J.A. Wells The Insulin-Like Growth Factor (IGF) Axis, P. Cohen and R.G. Rosenfeld Transgenic Mice in the Study of Growth Hormone and the Insulin-Like Growth Factors, A.J. D'Ercole Clinical Aspects of Growth Hormone Treatment of Children, A.D. Rogol Growth Hormone Receptor Deficiency, M.A. Vaccarello Growth Hormone, IGF-I and Human Aging, R. Marcus and A. Hoffman Effects of Human Growth Hormone in Older Adults, A.A. Abbasi and D. Rudman Growth Hormone Effects on the Immune System, D.A. Weigent and J. Edwin Blalock Spontaneous & Iatrogenic Hypersomatotropism, W.H. Daughaday Author Index Subject Index

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