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Author:   Laurence A. Cole (Director, USA hCG Reference Service, Santa Fe, New Mexico, USA) ,  Laurence Cole
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Elsevier Science Publishing Co Inc
Dimensions:   Width: 15.20cm , Height: 2.40cm , Length: 22.90cm
Weight:   0.740kg
ISBN:  

9780123849076

ISBN 10:   0123849071
Pages:   400
Publication Date:   21 September 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Replaced By:   9780128007495
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   In Print  
Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock.

Table of Contents

INTRODUCTION Chapter 1: THE EXPANDING WORLD OF hCG Robert Hussa Chapter 2: HISTORY AND INTRODUCTION TO HUMAN CHORIONIC GONADOTROPIN (hCG): ONE NAME FOR AT LEAST THREE INDEPENDENT MOLECULES Laurence Cole Chapter 3: INTRODUCTION TO PREGNANCY IMPLANTATION, VILLOUS FORMATION, AND HEMOCHORIAL PLACENTATION Laurence Cole GENETICS, SYNTHESIS, SECRETION, STRUCTURE, AND DEGRADATION OF hCG Chapter 4: THE MOLECULAR GENETICS OF hCG Stephen Butler Chapter 5: STRUCTURE, SYNTHESIS, SECRETION, AND FUNCTION OF hCG Laurence Cole, PhD and Stephen Butler Chapter 6: COMPARISSON OF STRUCTURES OF hCG AND HYPERGLYCOSYLATED hCG Laurence Cole Chapter 7: STRUCTURES OF FREE a-SUBUNIT AND FREE ß-SUBUNIT Laurence Cole Chapter 8: GLYCOBIOLOGY OF hCGAkira Kobata Chapter 9: DEGRADATION PRODUCTS OF hCG, HYPERGLYCOSYLATED hCG, AND FREE ß-SUBUNITLaurence Cole Chapter 10: THE THREE DIMENSIONAL STRUCTURE OF hCGLaurence Cole BIOLOGICAL FUNCTION OF hCG Chapter 11: PARADIGM SHIFT ON THE TARGETS OF hCG ACTIONS CV Rao Chapter 12: THE hCG RECEPTOR Laurence Cole and Stephen Butler Chapter 13: BIOLOGICAL FUNCTIONS OF HYPERGLCOSYLATED hCGLaurence Cole Chapter 14: BIOLOGICAL FUNCTION OF THE FREE BETA SUBUNIT: EXPRESSION AND TREATMENT TARGET IN CANCER Steven Butler and Ray Iles CLINICAL APPLICATIONS Chapter 15: USE OF hCG IN REPRODUCTIVE DYSFUNCTIONCisco Byrn Chapter 16: hCG IN THE IVF CLINICErvin Jones, Chapter 17: ILLICIT USE OF hCG IN DIETARY PROGRAMS AND USE TO PROMOTE ANABOLISM Laurence Cole hCG TESTS Chapter 18: ANTIBODYS FOR INTACT hCG, TOTAL hCG, FREE SUBUNITS, GLYCOSYLATION VARIANTS, AND hCG FRAGMENTSLaurence Cole Chapter 19: QUANTITATIVE hCG ASSAYSLaurence Cole Chapter 20: FALSE-POSITIVE hCG ASSAYS Laurence Cole Chapter 21: SPECIFICITY OF DIFFERENT hCG ASSAYSLaurence Cole Chapter 22: POINT-OF-CARE PREGNANCY TESTS Laurence Cole Chapter 23: OVER-THE-COUNTER PREGANCY TESTS Laurence Cole Chapter 24: hCG STANDARDS Ulf Stenman TEST APPLICATIONS Chapter 25: BACKGROUND hCG Laurence Cole Chapter 26: PREGNANCY TESTINGLaurence Cole Chapter 27: PREDICTING SPONTANEOUSLY ABORTED (SAB) PREGNANCIES Laurence Cole Chapter 28: hCG, HYPERGLYCOSYLATED hCG, AND FREE ß-SUBUNIT IN PREDICTING DOWN SYNDROME PREGNANCIES AND PREECLAMPSIA Laurence Cole Chapter 29: hCG IN MONITORING GESTATIONAL TROPHOBLASTIC DISEASES Laurence Cole Chapter 30: USE OF HYPERGLYCOSYLATED hCG AS A UNIQUE MARKER OF GESTATIONAL TROPHOBLASTIC NEOPLASMS Laurence Cole and Carolyn Muller Chapter 31: PITUITARY hCG AND FAMILIAL hCG Laurence Cole Chapter 32: hCG, FREE ß-SUBUNIT AND ß-CORE FRAGMENT AS MARKERS OF MALIGNANCIES Laurence Cole BASIC METHODS Chapter 33: hCG AND HYPERGLYCOSYLATED HCG PURIFICATION FROM SERUM, URINE, AND CULTURE FLUIDS Laurence Cole Chapter 34: DISSOCIATION, DESIALYLATION, AND CLEAVAGE OF HCG Laurence Cole Chapter 35: hCG AND FREE ß-SUBUNIT PRODUCING CELL LINES Laurence Cole EVOLUTION, SUMMARY AND THE FUTURE Chapter 36: EVOLUTION OF hCG, EVOLUTION OF HUMANS, EVOLUTION OF HUMAN PREGNANCY DISORDERS AND CANCERLaurence Cole Chapter 37: SUMMARY: hCG A REMARKABLE MOLECULELaurence Cole Chapter 38: hCG AND THE FUTURE Laurence Cole

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Dr. Cole has served on the journal editorial board from 1994-2001 as the Editor of ""Trophoblast Disease Update"". He has written more than 100 articles on hCG structure, physiology and immunoassay and on clinical applications of hCG or hCG-related molecules. He has a 1.17 FWCI in the Medicine category of SciVal where he has published throughout the various disciplines and maintains an average of 12.6 citations per article from 2009-2014. He has experience with international, single, and institutional collaboration. Awards and recognition for Dr. Cole include the Institute for Anticancer Research, Biannual Prize for best research; American Association for Clinical Chemistry, Most Outstanding Research Contributor to Clinical Chemistry Prize; Gynecology Oncology, Outstanding Speaker Award; and International Society for Study of Trophoblastic Disease, Gold Medal for most outstanding research.

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