Overview

All of us would like to live longer, or to slow the debilitating effects of age. In How We Age, Coleen Murphy shows how recent research on longevity and aging may be bringing us closer to this goal. Murphy, a leading scholar of aging, explains that the study of model systems, particularly simple invertebrate animals, combined with breakthroughs in genomic methods, have allowed scientists to probe the molecular mechanisms of longevity and aging. Understanding the fundamental biological rules that govern aging in model systems provides clues about how we might slow human aging, which could lead in turn to new therapeutics and treatments for age-related disease. Among other vivid examples, Murphy describes research that shows how changing a single gene in the nematode worm C. elegans doubles its lifespan, extending not only the end of life but also the youthful, healthy part of life. Drawing on work in her own lab as well as other recent research, Murphy chronicles the history and current state of the field, explaining longevity's links to reproduction and mating, sensory and cognitive function, inheritances from our ancestors, and the gut microbiome. Written with clarity and wit, How We Age provides a guide to the science: what we know about aging, how we know what we know, and what we can do with this new knowledge.

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Coleen T. Murphy is professor of genomics and molecular biology at Princeton University. She is director of Princeton's Glenn Foundation for Research on Aging and director of the Simons Collaboration on Plasticity in the Aging Brain. Rosemary Benson is an Audible #1 bestselling narrator, singer, educator, and stage actress. She has appeared across the US, Canada, and Italy, and regularly performs with several ensembles and big bands. As a passionate learner and audiobook fan, she strives to entertain, enlighten, and encourage, so she is at home in many genres. Her musical ear allows her to produce myriad accents for storytelling, while her expertise in differentiating instruction guides her abilities in nonfiction. She lives across the river from Philadelphia with her husband and a houseful of musical instruments and books.

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