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Th chapter d u th u f d m t r bb t n t x t and safety t t ng of substances u h drug , h m l , nd m d l d v th t can m t hum n f t . While non-clinical testing l b n f t animals with development of veterinary drug , th x m l nd r dur d r b d in th h t r r r nt those mm nl u d n r r h nd r gul t d non-clinical f t testing settings. Toxicity nd f t tud should lw be conducted in m l n w th l bl r gul t n , l w , policies, nd gu d l n w ll the r u r m nt f d by th facility's Institutional Animal Care nd U C mm tt (IACUC). D m t rabbits, Or t l gu un ulu , belonging t th rd r L g m r h nd the f m l L r d , are easily h u d nd h ndl d. R bb t r small r l t v t th r (m n g , d g , and m nk ) v lu t d n t x t nd f t studies, but l rg enough t l conduct ul r and d rm l irritation nd embryo-fetal v lu t n . Br d frequently u d n non-clinical tud include N w Z l nd Wh t (NZW) and Japanese lb n rabbits (3-5 kg r 6.6-11 lbs) nd th smaller, gm nt d Dutch Belted (0.9-1.8 kg; 2-4 lb ). Dutch B lt d rabbits r v d n dv nt g w th respect t th m unt of t t m t r l required ( r x m t l 40% less m r d with lb n r bb t ).

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