Overview

Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis. The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.

Full Product Details

Author:   Vincent Goffin ,  Paul A. Kelly
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 2002
Volume:   17
Weight:   0.510kg
ISBN:  

9781441949486

ISBN 10:   1441949488
Pages:   314
Publication Date:   17 September 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Awaiting stock  
The supplier is currently out of stock of this item. It will be ordered for you and placed on backorder. Once it does come back in stock, we will ship it out for you.

Table of Contents

Section I Fundamental Mechanisms in Signaling.- 1 Protein Phosphorylation and Protein-Protein Interactions.- 2 Control of Signaling by Tyrosine Phosphatases.- 3 Spatio-Temporal Parameters: The Case of the MAP Kinase Pathway.- Section II Receptor Tyrosine Kinases.- 4 The EGF Receptor Signaling System. A Model for Growth Factor Receptor Signaling.- 5 Insulin and Insulin-Like Growth Factor-1 Receptors and Signaling Pathways: Similarities and Differences.- Section III Cytokine Receptors.- 6 The JAK-STAT Pathway.- 7 Prolactin and Growth Hormone Receptors. Signal Transduction and Crosstalk.- 8 Erythropoietin, Thrombopoietin and Leptin Receptors.- Section IV G Protein-Coupled Receptors.- 9 G Proteins and G Protein-Coupled Receptors: Overview.- 10 Gonadotropin and TSH Receptors.- 11 Endothelin G Protein-Coupled Receptors.- Section V Nuclear Receptors.- 12 Signal Transduction and Structure of Nuclear Receptors.- 13 Estrogen Receptor Beta: How Awareness of ER? Affects Our Understanding of Estrogen Action.- 14 Sensors for Metabolic Control. A Regulatory Network of Nuclear Receptors.

Reviews

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions