Overview

Provides a unique summary of homologation strategies in organic synthesis Homologation Reactions presents different concepts underpinning the use of homologating reagents as well as their applications in organic synthesis. It covers in-depth discussions on the rationales governing this kind of transformations with a strong emphasis on mechanistic elements modulating critical aspects (e.g. selectivity) of the processes. In addition, this two-volume work features: Metal carbenoids, ylides, and diazo reagents Homologating agents working under nucleophilic, electrophilic, and radical regime Homologations realized on boron-containing or carbon-centered linchpins Use of highly sensitive fluorinated homologating agents Progressive homologations and the concept of assembly line synthesis Homologation processes followed by rearrangement cascades Construction of cyclic motifs and ring-expansion Homologation reactions with carbon monoxide and carbon dioxide New and/or challenging directions to expect in the future Written by an international team of leaders in the field, the book is a useful guide for designing effective transformations by using homologation reactions. It is a must-read for every synthetic chemist in academia and industry!

Full Product Details

Author:   Vittorio Pace (University of Torino, Italy; University of Vienna, Austria)
Publisher:   Wiley-VCH Verlag GmbH
Imprint:   Blackwell Verlag GmbH
Edition:   2 Volumes
Dimensions:   Width: 17.30cm , Height: 5.60cm , Length: 24.90cm
Weight:   2.064kg
ISBN:  

9783527348152

ISBN 10:   3527348158
Pages:   960
Publication Date:   19 July 2023
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

PART I. REAGENTS FOR HOMOLOGATIONS Diazomethane and Diazo-Based Reagents Lithium Carbenoids Microfluidic Technology as a Tool for Implementing Short-Lived C1-Delivering Agents Magnesium Carbenoids Zinc Carbenoids and Simmons-Smith-Type Processes Carbene-Transfer / Rearrangement Sequences Oxenoids Sulfur-Ylides Sulfoxonium-Ylides in C-H Activation Transformations Phosporous-Ylides for C2, C3 and C4-Homologations PART II. HOMOLOGATION OF BORON-CONTAINING PLATFORMS α-Boryl Carbanions Transition-Metal Free Homologation of Organoboron Compounds Stereospecific Reagent-Controlled Homologation of Boronic Esters Assembly-Line Synthesis PART III. HOMOLOGATION OF DEFINED PLATFORMS Fluorocarbon Chain Homologation Strategies for Accessing Fluorinated Elongated Skeletons Carbonyl- and Aza-Carbonyl Homologations Homologation-Functionalization of Aldehydes Ring Expansion Methodologies Ring Contraction Methodologies – Dehomologation Radical-Based Homologations Allenation of Terminal Alkynes Use of CO2 and CO as C1-Sources

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Author Information

Vittorio Pace is Full Professor of Organic Chemistry at the University of Torino, Italy, since 2020. Before, he held a tenure-track professorship in Drug Synthesis at the University of Vienna, Austria. He received his habilitation (venia docendi) in Pharmaceutical Chemistry from the University of Vienna in 2016. He has been the recipient of different awards including the Ciamician Medal of the Italian Chemical Society, La Roche-Hoffmann Prize of the European Society of Medicinal Chemistry, the Thieme Award, and the Habilitation Award of the Austrian Chemical Society. Prof. Pace is an elected member of the Royal Spanish Academy of Pharmacy. His research is focused on the design and development of new synthetic concepts with functionalized organometallic reagents with a strong focus on homologation sequences.

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