Overview

To date, evidence strongly supports the hypotheses that hyperhomocysteinemia is a strong independent determinant of vascular disease, and that many cases of hyperhomocysteinemia are amenable to homocysteine-lowering treatment with B-vitamins. The strength of this evidence is prompting discussion of large-scale homocysteine-lowering interventions. This wide-ranging treatise on homocysteine covers the topic from the basic biochemical, metabolic, genetic and dietary determinants to disease relationships, including concepts of pathogenesis. It also describes the public-health implications of these associations.

Full Product Details

Author:   Ian Graham ,  Helga Refsum ,  Irwin H. Rosenberg ,  Per Magne Ueland
Publisher:   Springer
Imprint:   Springer
Edition:   1997 ed.
Volume:   196
Dimensions:   Width: 17.80cm , Height: 1.70cm , Length: 25.40cm
Weight:   1.720kg
ISBN:  

9780792399834

ISBN 10:   0792399838
Pages:   279
Publication Date:   31 December 1997
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

I. Biochemistry And Genetic Studies.- 1. The Regulation of Homocysteine Metabolism.- 2. Methionine Kinetics and Balance.- 3. On the Formation and Fate of Total Plasma Homocysteine.- 4. Methylenetetrahydrofolate Reductase: Comparison of the Enzyme from Mammalian and Bacterial Sources.- 5. Genetics of Mammalian 5,10-methylenetetrahydrofolate Reductase.- 6. Thermolabile Methylenetetrahydrofolate Reductase.- 7. The Long-term Outcome in Homocystinuria.- 8. Characterization of the Human and Porcine Methionine Synthases and their Redox Partners.- 9. Inherited Disorders of Folate and Cobalamin.- 10. Molecular Genetics of Cystathionine ?-Synthase in Homocystinuria and Vascular Disease.- 11. Cystathionine ?-synthase Deficiency: Metabolic Aspects.- II. Vitamins, Pathology, And Drug Therapy.- 12. Homocysteine and Other Metabolites in the Diagnosis and Follow-up of Cobalamin and Folate Deficencies.- 13. Vitamin Status and Hyperhomocysteinemia in a Healthy Population.- 14. Association Between Plasma Homocysteine, Vitamin Status, and Extracranial Carotid-Artery Stenosis in the Framingham Study Population.- 15. Treatment of Mild Hyperhomocysteinemia.- 16. Folate, Vitamin B12, and Neuropsychiatric Disorders.- 17. Vitamins, Homocysteine, and Neural-Tube Defects.- 18. The Etiology of Neural Tube Defects.- 19. Plasma Homocysteine in Renal Failure, Diabetes Mellitus, and Alcoholism.- 20. Homocysteine and Drug Therapy.- III. Homocysteine, Cancer, And Cardiovascular Disease.- 21. Is Methionine Useful for the Prevention of Hyperhomocysteinemia-Associated Cardiovascular Disease?.- 22. Synthesis of Homocysteine Thiolactone in Normal and Malignant Cells.- 23. Folate Status: Modulation of Colorectal Carcinogenesis.- 24. The Hordaland Homocysteine Study: Lifestyle and Total Plasma Homocysteine inWestern Norway.- 25. Blood Homocysteine Levels in the National Health and Nutrition Examination Survey (NHANES III) in the United States: Preliminary Findings by Age and Sex.- 26. Heritability of Plasma Homocysteine Concentration.- 27. Plasma Homocysteine and Coronary Artery Disease.- 28. Homocysteine and Cerebral and Peripheral Vascular Disease.- 29. Plasma Homocysteine and its Relationship to Cardiovascular Risk Factors in a Japanese Population.- 30. Biological Chemistry of Thiols in the Vasculature and in Vascular-Related Disease.- IV. Intervention Studies and Concepts for the Future.- 31. Homocysteine and Vascular Disease: The European Concerted Action Project.- 32. Prospective Studies of Homocysteine and Vascular Disaese.- 33. A Meta-Analysis of Plasma Homocysteine as a Risk Factor for Arteriosclerotic Vascular Disease and the Potential Preventive Role of Folic Acid.- 34. Pathology of Homocystinuria.- 35. Lipoprotein(a), Homocysteine, and Atherogenesis.- 36. Endothelial- and Leukocyte-Mediated Mechanisms in Homocysteine-Associated Occlusive Vascular Disease.

Reviews

'This book is a good resource for information on homocysteine. It is well organised with short and concise chapters that have lots of diagrams, figures and tables...It is well suited for professionals in the field of cardiology and for those who are basic science researchers wishing a connection with clinical applications.' K. Cochan, M.D., Loyola University Stritch School of Medicine

'This book is a good resource for information on homocysteine. It is well organised with short and concise chapters that have lots of diagrams, figures and tables...It is well suited for professionals in the field of cardiology and for those who are basic science researchers wishing a connection with clinical applications.' K. Cochan, M.D., Loyola University Stritch School of Medicine

'This book is a good resource for information on homocysteine. It is well organised with short and concise chapters that have lots of diagrams, figures and tables...It is well suited for professionals in the field of cardiology and for those who are basic science researchers wishing a connection with clinical applications.' K. Cochan, M.D., Loyola University Stritch School of Medicine

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