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OverviewThis book gathers a series of pivotal papers on the development of an HIV/AIDS vaccine published in the last two decades. Accompanied by extensive comments putting the material into an up-to-date context, all three parts of the book offer a broad overview of the numerous unsuccessful attempts made in recent years to develop a preventive HIV vaccine. Providing a detailed review and analysis of studies published from 1998 to the present day, it examines the likely reasons for the failure to develop an HIV vaccine despite multi-million dollar investments. Full Product DetailsAuthor: Marc H V Van RegenmortelPublisher: Springer Nature Switzerland AG Imprint: Springer Nature Switzerland AG Edition: 1st ed. 2019 Weight: 0.707kg ISBN: 9783030324612ISBN 10: 3030324613 Pages: 364 Publication Date: 10 December 2020 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsIntroduction Part I Immunochemistry 1 What is a B cell epitope 2 Molecular design versus empirical discovery in peptide-based vaccines. Coming to terms with fuzzy recognition sites and ill-defined structure–function relationships in immunology 3 Synthetic Peptide Vaccines and the Search for Neutralization B Cell Epitopes# 4 Specificity, polyspecificity, and heterospecificity of antibody‐antigen recognition Part II Reductionism 5 Reductionism and the search for structure–function relationships in antibody molecules 6 Reductionism and complexity in molecular biology 7 Editorial: Biological complexity emerges from the ashes of genetic reductionism 8 The rational design of biological complexity: A deceptive metaphor 9 Basic research in HIV vaccinology is hampered by reductionist thinking 10 Commentary: Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking 11 Nature and Consequences of Biological Reductionism for the Immunological Study of Infectious Diseases Part III Vaccinology 12 Limitations to the structure‐based design of HIV‐1 vaccine immunogens 13 Two meanings of reverse vaccinology and the empirical nature of vaccine science 14 Requirements for empirical immunogenicity trials, rather than structure-based design, for developing an effective HIV vaccine. 15 Paradigm Changes and the Future of HIV Vaccine Research: A Summary of a Workshop Held in Baltimore on 20 November 2013 16 Editorial: Paradigm changes are required in HIV vaccine research 17 An outdated notion of antibody specificity is one of the major detrimental assumptions of the structure-based reverse vaccinology paradigm, which prevented it from helping to develop an effective HIV-1 vaccine 18 More surprises in the development of an HIV vaccine 19 Why Does the Molecular Structure of Broadly Neutralizing Monoclonal Antibodies Isolated from Individuals Infected with HIV-1 not Inform the Rational Design of an HIV-1 Vaccine? 20 Old and New Concepts and Strategies in HIV Vaccinology: A Report from a Workshop held in Rome on 17 June 2016 21 Structure-Based Reverse Vaccinology Failed in the Case of HIV Because it Disregarded Accepted Immunological Theory 22 Immune systems rather than antigenic epitopes elicit and produce protective antibodies against HIV. 23 Development of a Preventive HIV Vaccine Requires Solving Inverse Problems Which Is Unattainable by Rational Vaccine Design 24 Viral species, viral genomes and HIV vaccine design: is the rational design of biological complexity a utopia?ReviewsAuthor InformationMarc Van Regenmortel was a Professor of Virology at various Universities in South Africa (Stellenbosch and Cape Town) and France (Strasbourg), and was head of the Immunochemistry Laboratory at the CNRS Molecular Biology Institute in Strasbourg for 22 years. He served as President of the International Committee on Taxonomy of Viruses and published a dozen books and 420 papers and reviews on the immunochemistry of peptides and viruses, viral taxonomy and biosensor technology. He was an advisor to the South African AIDS Vaccine Initiative and is currently an associate editor of Journal of Molecular Recognition, Archives of Virology, Advances in Virus Research, Journal of Immunological Methods, Analytical Biochemistry and Frontiers in Immunology. He is an Adjunct Professor of the Medical University of Vienna. Tab Content 6Author Website:Countries AvailableAll regions |
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