Overview

Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling.  These signals also are responsible for leukocytic infiltration into the submucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, it is well appreciated that asthma is a heterogeneous in terms of onset, exacerbants, severity, and treatment response.  Current asthma classification methods are largely descriptive and focus on a single aspect or dimension of the disease.  An active area of investigation on how to collect, use and visualize multidimensional profiling in asthma.  This book will overview multidimensional profiling strategies and visualization approaches for phenotyping asthma.  As an outcome, this work will facilitate the understanding of disease etiology, prognosis and/or therapeutic intervention. ​ 

Full Product Details

Author:   Allan R. Brasier
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   Softcover reprint of the original 1st ed. 2014
Volume:   795
Dimensions:   Width: 15.50cm , Height: 2.00cm , Length: 23.50cm
Weight:   5.562kg
ISBN:  

9781489978295

ISBN 10:   1489978291
Pages:   354
Publication Date:   23 August 2016
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Introduction: Applications of Translational Science to Clinical Problems.- Section I:  Spectrum of Asthma.- Introduction to spectrum of asthma.- 1. Introduction to Asthma and Phenotyping.- 2. Epidemiology of Asthma.- 3. Heterogeneity of asthma in society.- 4. Allergens and Environmental Association to Asthma.- 5. Current Clinical Diagnostic Tests for Asthma.- 6. Management of Asthma: the current US and European Guidelines.- 7. Community Interventions in Asthma.- 8. Heterogeneity of Response to Therapy.- Section II: Genetics and Genomics in Asthma.- Introduction to genetics and genomics in asthma.- 9. Genetics of Asthma.- 10. Genomics of Asthma.- 11. Epigenetics of Asthma.- Section III: Proteomics, Metabolomics, and Systems Biology of Asthma.-11. Introduction to proteomics, metabolomics and systems biology of asthma.- 12. Overview of Proteomics in Airway Disease.- 13. Metabolomics in Asthma.- 14. Overview on Methods of Sample Preparation.- 15. Measurement of Innate Immunity in the Airway.- 16. Functional Proteomics in Isolated Cells for Steroid Response.- Section IV:   Modeling Complex Data  in Asthma.- Introduction to modeling complex data in asthma.- 17. Biostatistical Analysis and Predictive Modeling in Asthma Phenotype.- 18. Role of Visual Analytics in Asthma Phenotyping and Complex Data Analysis.- Section V: Biobehavioral Determinants  in  Asthma.- Introduction to biobehavioral determinants.- 19. Central Nervous System Influences in Asthma.- 20. Social and Cultural Influences in Asthma Diagnosis and Management.- Section VI: Conclusions and Future Directions.- Summary

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