Overview

The herpes group consists of viruses which have been placed together on the basis of a number of distinguishing features that they share in common (ANDRE­ WES, 1962). All these viruses are relatively large, possess identical morphological characteristics, contain DNA, and are extremely sensitive to inactivation by ether; these viruses are also assembled within the nucleus of the host cell and induce the formation of eosinophilic intranuclear inclusions. The epidemiology of some of the best known viruses in this group (herpes simplex, pseudorabies, and B-virus) is also similar (BURNET et aI. , 1939). Herpes simplex virus exists in the latent state in man, the natural host for this virus, and becomes overt in individuals subject to some form of stress; this condition appears to be paralleled by pseudorabies virus in its natural host, swine and by B-virus in monkeys. In each instance, transmission of the virus to a susceptible host other than the natural one results usually in marked symptoms and death. This chapter is confined to a description of herpes simplex and pseudorabies viruses; B-virus is described separately elsewhere in the Hand book. Since the clinical aspects of the diseases caused by herpes simplex virus and pseudorabies virus have been well described, greater emphasis will be placed, therefore, on the basic biological and biochemical properties of these viruses; their clinical features will be discussed only briefly.

Full Product Details

Author:   Albert S. Kaplan
Publisher:   Springer Verlag GmbH
Imprint:   Springer Verlag GmbH
Edition:   Softcover reprint of the original 1st ed. 1969
Volume:   5
Dimensions:   Width: 17.00cm , Height: 0.70cm , Length: 24.40cm
Weight:   0.229kg
ISBN:  

9783709182314

ISBN 10:   370918231
Pages:   118
Publication Date:   16 January 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

I. Introduction.- II. History.- A. Herpes Simplex Virus.- B. Pseudorabies Virus.- III. Classification and Nomenclature.- IV. Properties of the Viruses.- A. Morphology.- B. Physical-chemical Structure.- C. Antigenic Structure.- D. Eesistance to Physical and Chemical Agents.- V. Cultivation.- A. Host Range.- B. Environmental Factors that Affect Virus Formation.- C. Virus Growth Cycle.- D. Plaque Formation.- VI. Cytopathogenicity.- A. Cross Cytopathology.- B. Intranuclear Alterations.- C. Chromosomal Alterations.- VII. Metabolism of Infected Cells.- A. Technical Problems in the Chemical Analysis of Cells Infected with the Herpes Viruses.- B. DNA Synthesis.- C. RNA Synthesis.- D. Protein Synthesis.- E. Site of Synthesis of Viral Components.- F. Virus Assembly.- G. Enzymology of the Virus-infected Cells.- H. Control of the Infective Process.- I. Molecular Viral Chemotherapy.- VIII. Abortive Infection.- IX. Pathogenesis.- A. Susceptible Animals.- B. Influence of the Age of Animals on Pathogenicity of Herpes Simplex and Pseudorabies Viruses.- C. Dynamics of Development of Disease.- X. Variation.- A. Virulence and Cytopathogenicity.- B. Conditional Lethal Mutants.- C. Drug-resistant Mutants.- XI. Immunity.- A. Active Immunization.- B. Passive Immunization.- C. Interference and Interferon.- XII. Essential Clinical Features.- A. Herpes Simplex Virus.- B. Pseudorabies Virus.- XIII. Pathology.- A. Herpes Simplex Virus.- B. Pseudorabies Virus.- XIV. Diagnosis.- A. Herpes Simplex Virus.- B. Pseudorabies Virus.- XV. Treatment.- XVI. Epidemiology.- A. Herpes Simplex Virus.- B. Pseudorabies Virus.- XVII. Latent and Persistent Virus.- XVIII. Abbreviations.- References.

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