Overview

Malignant neoplasms occurring in the biliary tract and pancreas remain a therap- tic challenge. The mechanism of carcinogenesis as well as the growth and spread of these tumors is still poorly understood, making the development of rational tre- ment strategies difficult. In order to improve the clinical results achieved by sur- cal or other medical treatment of such malignant tumors, the establishment of an experimental animal model is critical. For this purpose, attempts were made to induce carcinoma experimentally in the biliary tree and finally an animal model using the hamster was established in 1994 at our laboratory. Because the tumor in this model mimicked the characteristics of human tumors, a series of experimental investigations were conducted to clarify the pathological characteristics of biliary carcinoma, the genetic alterations during biliary carcinogenesis, and the relationship between biliary inflammation and c- cinogenesis. The chemopreventive effects on the occurrence of biliary carcinoma were also successfully examined. In addition, in vitro studies led to the establi- ment of transplantable biliary cancer cell lines and biliary epithelial cell lines by utilizing the hamster model. This monograph represents the collective efforts in hepato-biliary and pancreatic disease research over the past 20 years. I hope that this monograph will be a source of useful knowledge for basic researchers as well as for clinicians involved in the care of patients with hepato-biliary and pancreatic neoplasms. Takashi Kanematsu, M.D., Ph.D.

Full Product Details

Author:   Yoshitsugu Tajima ,  Tamotsu Kuroki ,  Takashi Kanematsu
Publisher:   Springer Verlag, Japan
Imprint:   Springer Verlag, Japan
Edition:   Softcover reprint of hardcover 1st ed. 2009
Dimensions:   Width: 15.50cm , Height: 1.30cm , Length: 23.50cm
Weight:   0.397kg
ISBN:  

9784431998594

ISBN 10:   4431998594
Pages:   241
Publication Date:   21 October 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

General Information.- The Syrian Hamster as an Experimental Animal.- Surgical Instruments.- Anesthesia of the Laboratory Hamster.- Fundamental Surgical Techniques.- Experimental Carcinogenesis in the Hamster.- Hamster Models of Biliary Carcinoma.- Biliary Carcinomas Induced in the Hamster.- Biliary Inflammation and Biliary Carcinogenesis.- Spontaneous Biliary Carcinogenesis.- Modification of Biliary Carcinogenesis.- Chemoprevention of Biliary Carcinogenesis.- Hamster Model of an Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas.- Chemoprevention of Pancreatic Carcinogenesis.- Cancer Lines and Biliary Epithelial Cell Lines.- Establishment of Transplantable Biliary Cancer Lines.- Establishment of Biliary Epithelial Cell Lines from the Hamster.

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