Overview

A collection of readily reproducible experimental and clinical techniques for studying the molecular basis of hemoglobin disorders. These step-by-step methods utilize a wide variety of the latest analytical techniques, including x-ray crystallography, high performance liquid chromatography, electrophoresis, and nuclear magnetic resonance. Additional methods are offered for prenatal diagnostic analysis, the DNA diagnosis of hemoglobin mutations, hemoglobin fluorescence, and the semisynthesis of hemoglobin.

Full Product Details

Author:   Ronald L. Nagel
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2003 ed.
Volume:   82
Dimensions:   Width: 15.50cm , Height: 1.90cm , Length: 23.50cm
Weight:   0.653kg
ISBN:  

9780896039629

ISBN 10:   0896039625
Pages:   300
Publication Date:   04 March 2003
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of print, replaced by POD  
We will order this item for you from a manufatured on demand supplier.

Table of Contents

X-ray Crystallography of Hemoglobins.- Analysis of Hemoglobins and Globin Chains by High-Performance Liquid Chromatography.- Purification and Molecular Analysis of Hemoglobin by High-Performance Liquid Chromatograpy.- Oxygen Equilibrium Measurements of Human Red Blood Cells.- Measurement of Rate Constants for Reactions of O2, CO, and NO with Hemoglobin.- Electrophoretic Methods for Study of Hemoglobins.- DNA Diagnosis of Hemoglobin Mutations.- Methods for Analysis of Prenatal Diagnosis.- Hemoglobin Fluorescence.- Nucleation and Crystal Growth of Hemoglobins.- Semisynthesis of Hemoglobin.- ?-Globin-like Gene Cluster Haplotypes in Hemoglobinopathies.- Transgenic Mice and Hemoglobinopathies.- Recombinant Single Globin-Chain Expression and Purification.- Nuclear Magnetic Resonance of Hemoglobins.- Solubility Measurement of the Sickle Polymer.

Reviews

.,. the book is a very good practical volume for those interested in further clinical and experimental studies of hemoglobin disorders. - Biomedical Chromatography

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