Overview

Type-2 diabetic nephropathy is one of the major long-term microvascular complications occurring in nearly 40 per cent of diabetic patients in Japan. The purpose of this book is to review recent work on the genetic background, pathogenesis and treatment of this disorder and to provide the most up-to-date findings on these subjects in Japan. The pathogenesis of diabetic nephropathy includes both metabolic and/or hemodynamic factors, as well as renal hypertrophy. Hyperglycemia is necessary, but not sufficient, for its initiation and progression: The toxicity of persistent hyperglycemia results from glucose overutilization and multiple secondary effects. Moreover, diabetic nephropathy is generally considered to alter the chemical composition of the glomerular basement membrane and mesangium. At present, it is supposed that the increases in extracellular matrix accumulation due to TGF-beta activation might be related to the glomerular sclerosis in diabetic nephropathy. Although large numbers of candidate genes have been analyzed, those related to initiation and progression are still obscure in patients with type-2 diabetic nephropathy. Presenting clinical findings and issues related to laboratory analysis, this book should be of interest for nephrologists, diabetologists, pathologists, biochemists, general physicians and residents.

Full Product Details

Author:   C. Ronco ,  G. La Greca ,  Claudio Ronco
Publisher:   S Karger AG
Imprint:   S Karger AG
Edition:   illustrated edition
Volume:   137
Dimensions:   Width: 17.30cm , Height: 2.50cm , Length: 24.40cm
Weight:   1.120kg
ISBN:  

9783805574235

ISBN 10:   3805574231
Pages:   450
Publication Date:   31 May 2002
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Awaiting stock  
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Table of Contents

Basic findings: genetic background - patients, Y. Maita, Y. Tomino; animal models, T. Shike, K. Funabiki, Y. Tomino ; mesangial cell dysfunction as a pathogenesis of diabetic nephropathy, M. Haneda, D. Koya, R. Kikkawa ; advanced glycation end products and the pathogenesis of diabetic nephropathy, S.-I. Yamagishi, M. Takeuchi, Z. Makita ; carbonyl stress, D. Suzuki, T. Miyata, K. Kurokawa; role of macrophages in the pathogenesis of diabetic nephropathy, K.-i. Shikata, H. Makino ; lipid abnormality, M. Mune, H. Otani, K. Kimura; impairment of ECM production, S. Horikoshi, Y. Kanamaru, K. Funabiki, Y. Tomino; podocyte loss and progression of diabetic nephropathy, I. Shirato, T. Hishiki, Y. Tomino; efficacy of ACE inhibitor (Captopril) on glomerular antioxidant enzyme activity and hypertension in diabetic hypertensive rats, I. Shou, M. Fukui, Y. Tomino. Clinical findings and treatment: classification of Type-2 diabetic nephropathy in Japan, Y. Tomino; serum cystatin, C Y. Tomino; urinary type-IV collagen; Y. Tomino; urinary albumin fragments, M. Yagame, H. Sakai ; renal biopsy findings and clinical course, S.-i. Nishi, M. Ueno, F. Gejyo ; blood glucose control, H. Uchino, R. Kawamori; blood pressure control in diabetic nephropathy, S. Katayama; dietary protein restriction and nutritional adequacy in diabetic nephropathy, M. Kanauchi; future strategy - gene therapy for diabetic nephropathy, Y. Isaka, E. Imai.

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