Overview

Heme oxygenase is an enzyme which breaks down heme, the iron-containing oxygen-carrying constituent of the red blood cells. Heme must be synthesised and degraded within an individual nucleated cell, as heme is essential for the maintenance of cellular homeostasis by sensing or using oxygen. Physiological heme degradation is catalysed by the two functional isozymes of heme oxygenase, heme oxygenase-1 (HO-1) and HO-2, yielding CO, iron, and biliverdin IXN. Heme oxygenase-1 (HO-1), has potent anti-inflammatory, anti-oxidant and anti-proliferative effects, is up-regulated by multiple stimuli and provides protection against oxidative stress. HO-1 also plays an important role in the regulation of cardiovascular function and is involved in many other diseases such as sickle cell disease. This new book brings together leading research from around the world in this field.

Full Product Details

Author:   Leo E Otterbein ,  Brian S Zuckerbraun
Publisher:   Nova Science Publishers Inc
Imprint:   Nova Science Publishers Inc
Weight:   1.145kg
ISBN:  

9781594544477

ISBN 10:   1594544476
Pages:   417
Publication Date:   06 June 2005
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Available To Order  
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Table of Contents

Preface: The Cain Mutiny; Heme Oxygenase and Human Disease; The Role of Heme Oxygenase-1 Promoter Polymorphisms in Human Disease; Hematophagy and heme toxicity: What can we learn from natural-born vampires?; Heme Oxygenase-1 in Cardiovascular Biology; Heme Oxygenase-1: A Potential Modulator of Inflammation and Vaso-occlusion in Sickle Cell Disease; Heme Oxygenase and the Gastroenterological System; Novel Functions of Heme Oxygenase Protein; Heme Oxygenase-1: A protective gene that regulates inflammation and immunity; Heme Oxygenase-1 (HO-1) in Transplantation; Carbon Monoxide-Releasing Molecules (Co-Rms): A Stratagem to Emulate the Beneficial Effects of Heme Oxygenase-1; Heme Oxygenase-1: Linking Signal Transduction to Function; Role of heme oxygenase-1 and carbon monoxide in ischemia reperfusion injury; Heme oxygenase-1 and angiogenesis: therapeutic implications; Reciprocal regulation of heme oxygenases and nitric oxide synthases the modulation of biochemical and physiological functions; Biliverdin Reductase - a reassessment of Its functions in the light of recent discoveries; Antioxidant defence mechanisms By Heme Oxygenase and bile pigments; Heme oxygenase V a crucial enzyme in iron and heme homeostasis; Heme, Heme Oxygenase and Ferritin in Vascular Endothelial Cell Injury; Heme Oxygenase-1 Gene Regulation: Transcription Factors and Transduction Pathways; Index.

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