Overview

Hematopoietic genes play an important role in the development of blood cells and the immune system. Low birth weight (LBW) newborns are at an increased risk for various health problems, including hematological disorders. An in-silico approach is a computational method used to study and analyze biological data, such as genetic information. In the case of LBW newborns, an in-silico approach can be used to study the genetic factors that contribute to hematopoiesis and the development of hematological disorders. This can involve analyzing the genetic makeup of LBW newborns and comparing it to that of normal birth weight newborns to identify genetic variations or mutations that may be associated with LBW and hematological disorders. This can also include bioinformatics tools for functional annotation of identified genetic variations to understand the role of these genes in hematopoiesis, and potentially identify novel therapeutic targets for hematological disorders in LBW newborns. Neonatal deaths are a serious concern worldwide, although their magnitude varies significantly between the developed and developing countries, notably higher among developing countries. The duration of the neonatal period as globally accepted begins at birth and ends after 28 completed days of life, the period, which is recognized as the most susceptible time for a newborn's life . With about 7 million neonatal cases and 700,000 deaths per year, infection in neonates is a common tragedy, currently responsible for 40 per cent of mortality in those under five years of age . According to one estimate, nearly 5 million neonates die per year globally, of which 0.75 million are in developing countries, including India . The total number of neonatal mortality reductions depends on India, which accounts for about a fifth of the global total . In India, the neonatal mortality rate has decreased by 62% from 125 per thousand newborns in 1990 to 47 per thousand newborns in 2015, marginally 66% reduction proposed by million death study collaborators . The newborns with bodyweight less than 2500 grams are called Low Birth Weight (LBW) newborns. These newborns have higher rate of mortality and morbidity compared to Normal Birth Weight (NBW) newborns .

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