Overview

Three a.m., the call comes from the floor: the patient with newly diagnosed AML now has a platelet count of eight, a fever of 39.4, and a creatinine that has doubled in twelve hours - and the decisions you make in the next twenty minutes will determine whether tomorrow morning brings a recovery or a code. When generalist instincts replace hematology-specific reasoning, the consequences arrive fast: the missed acute chest syndrome, the unrecognized TTP treated as ITP, the tumor lysis that should have been prevented, the cord compression that becomes paraplegia. This handbook delivers the clinical reasoning, evidence base, and decision-making frameworks that transform hematologic care from reactive pattern-matching into anticipatory, guideline-grounded practice at the bedside. Inside this book: - Diagnose with confidence - work up cytopenias, hemolysis, and lymphadenopathy using structured algorithms that produce the diagnosis, not just a long differential - Treat the newest AML - apply venetoclax-azacitidine, FLT3 inhibitors, and the IDH-targeted agents reshaping leukemia care - Anticoagulate the complex patient - choose between apixaban, warfarin, and LMWH using the evidence from CARAVAGGIO, AMPLIFY-EXT, and TRAPS - Manage CAR-T toxicity - grade CRS and ICANS using ASTCT consensus criteria and intervene before deterioration - Recognize the emergency - identify tumor lysis, leukostasis, acute chest syndrome, and CAPS in the first ten minutes - Apply the 2024 paradigm shifts - nivolumab-AVD per SWOG S1826, D-VRd per PERSEUS, second-line CAR-T per ZUMA-7 - Transfuse restrictively - apply 2023 AABB thresholds across cardiac surgery, sepsis, and GI bleeding - Navigate special populations - manage hematologic disease in pregnancy, frailty, and geriatric complexity Written for internal medicine residents, hospitalists, hematology fellows, NPs, PAs, and the medical students rotating through hematology services. Order this handbook now and bring contemporary hematology to every patient on your service.

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