Overview

Hedgehog Signaling: From Origins to Therapies is an in-depth survey of current understanding of Hedgehog signaling biology. Divided into three parts, the book covers mechanisms of action and evolution of the HH pathway; the biological functions of Hh, (principally in vertebrates); and clinical consequences of Hh dysfunction and the modulation of Hh signaling in regenerative medicine and cancer therapy. Accessible to a wide readership, from advanced students to clinical practicioners, Hedgehog Signaling provides comprehensive coverage of how Hedeghog proteins are processed and secreted, how they are received and interpreted by cells, and the various ways in which they control the proliferation and differentiation of a diverse range of cell types. Designed as a reference for both researchers and clinicians interested in the pathological consequences of Hh dysfunction, as well as its potential for therapeutic applications, Hedgehog Signaling will also be a useful resource for all those interested in cell signalling in development, health and disease.

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9781118524831

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