Overview

Systems Biology is now entering a mature phase in which the key issues are characterising uncertainty and stochastic effects in mathematical models of biological systems. The area is moving towards a full statistical analysis and probabilistic reasoning over the inferences that can be made from mathematical models. This handbook presents a comprehensive guide to the discipline for practitioners and educators, in providing a full and detailed treatment of these important and emerging subjects. Leading experts in systems biology and statistics have come together to provide insight in to the major ideas in the field, and in particular methods of specifying and fitting models, and estimating the unknown parameters. This book: Provides a comprehensive account of inference techniques in systems biology. Introduces classical and Bayesian statistical methods for complex systems. Explores networks and graphical modeling as well as a wide range of statistical models for dynamical systems. Discusses various applications for statistical systems biology, such as gene regulation and signal transduction. Features statistical data analysis on numerous technologies, including metabolic and transcriptomic technologies. Presents an in-depth presentation of reverse engineering approaches. Provides colour illustrations to explain key concepts. This handbook will be a key resource for researchers practising systems biology, and those requiring a comprehensive overview of this important field.

Full Product Details

9780470710869

Table of Contents

Reviews

A very remarkable collection of essays. Strongly recommended to workers in this area. ( International Statistical Review , 1 October 2013) I would highly recommend this book as a useful guide for the students and practitioners of systems biology. ( Science Progress , 1 September 2012) This handbook will be a key resource for researchers practising systems biology, and those requiring a comprehensive overview of this important field. ( Zentralblatt MATH , 2012)

<p> This handbook will be a key resource for researchers practising systems biology, and those requiring a comprehensive overview of this important field. ( Zentralblatt MATH , 2012)

A very remarkable collection of essays. Strongly recommended to workers in this area. (International Statistical Review, 1 October 2013) I would highly recommend this book as a useful guide for the students and practitioners of systems biology. (Science Progress, 1 September 2012) This handbook will be a key resource for researchers practising systems biology, and those requiring a comprehensive overview of this important field. (Zentralblatt MATH, 2012)

<p> A very remarkable collection of essays. Strongly recommended to workers in this area. (International Statistical Review, 1 October 2013) <p> I would highly recommend this book as a useful guide for the students and practitioners of systems biology. (Science Progress, 1 September 2012) <p> This handbook will be a key resource for researchers practising systems biology, and those requiring a comprehensive overview of this important field. (Zentralblatt MATH, 2012)

Author Information

Michael Stumpf, Theoretical Systems Biology at Imperial College London David Balding, Statistical Genetics in the Institute of Genetics at University College London Mark Girolami, Department of Computing Science and the Department of Statistics

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