Overview

This publication reviews blood platelet biochemistry, physiology, pharmacology and function. It provides up-to-date information on how platelets function, the biochemical mechanisms that modulate their physiology and function, as well as the pharmacology of platelet inhibitory drugs. The book presents an overview of biochemistry, receptor biology, signaling mechanisms, calcium homeostasis, molecular pathology, and comparative physiology of platelets, as well as the pharmacology of antiplatelet drugs and clinical trials. It should prove a useful reference for haematologists, cell biologists, biochemists, pathologists, and other researchers in the areas of cell biology, pathobiology, atherosclerosis, thrombosis, and biomedical engineering.

Full Product Details

Author:   Gundu H.R. Rao
Publisher:   Springer
Imprint:   Springer
Edition:   Softcover reprint of the original 1st ed. 1999
Dimensions:   Width: 15.50cm , Height: 3.10cm , Length: 23.50cm
Weight:   2.150kg
ISBN:  

9780792385387

ISBN 10:   0792385381
Pages:   553
Publication Date:   30 June 1999
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Contributors. Preface. Introduction. 1. Platelet Physiology & Pharmacology: An overview; G.H.R. Rao. Receptor Biology. 2. Human Platelet Thrombin Receptors and the two Receptor Model for Platelet Activation; G.A. Jamieson, et al. 3. Platelet Thromboxane Receptors: Biology and Function; G.J. Johnson. 4. Collagen Receptors: Biology and Functions; B. Kehrel. 5. Adenosine Receptors: Biology and Function; K.C. Agarwal. 6. Platelet Activating Factor and Platelets; S.D. Shukla. 7. Platelet Glycoprotein 1b-V-1X: Biology and Function; K.J. Clemetson. 8. Fibrinogen Receptors: Biology and Function; E.I. Peerschke. Platelet Biochemistry. 9. Biochemistry of Platelet Activation; A. Ryningen, H. Holmsen. 10. GTP Binding Proteins in Platelets; B.R. Lester. 11. Platelet Cyclic Nucleotide Phosphodiesterases; R.W. Colman. 12. Polyenoic Fatty Acids and Platelet Function; M. Murthy. 13. Phospholipase A2 in Platelets; M. Murthy. Experimental Physiology. 14. Platelet Biorheology: Adhesive Interactions in Flow; M.M. Frojmovic. 15. Platelet Vessel Wall Interactions; G. Escolar, M. Diaz-Ricart. 16. Platelet-Biomaterial Interactions; T. Chandy and G.H.R. Rao. 17. Comparative Physiology of Platelets from Different Species; D.J. Weiss. Platelet Pathology. 18. The Molecular Pathology of Glanzmann's Thrombasthenia; D. French. 19. Congenital Disorders of Platelet Signal Transduction and Secretion; A. Koneti Rao. 20. Biochemistry of Altered Platelet Reactivity in Hypertension; Huzoor-Akbar. Platelet Pharmacology. 21. Nitric Oxide-mediated Regulation of Platelet Function; M.W. Radomski, A.S. Rodomski. 22. Aspirin, Prostaglandins and Platelet Function: Pharmacology and Thrombosis Prevention; D.C. Calverley, G.J. Roth. 23. Current Developments in Anticoagulant and Antithrombotic Agents; J. Fareed, et al. 24. Randomized Trials of Antiplatelet Therapy; C. Sudlow, C. Baigent. Subject Index.

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