Overview

This comprehensive, up-to-date reference work compiles the scientific research on the relationship between various forms of cancer and reactive oxygen species (ROS). It is well known that ROS play a key role in the various steps leading to malignancy, this includes increase in DNA mutation rates. The book brings together exciting reviews, written by leading experts all over the world. The book is divided into four broad sections. Each section describes the role of oxidative stress and underlying mechanisms and pathways, at various stages of cancer, including its role in carcinogenesis, cancer progression and metastasis. Further, the book describes how the reactive oxygen species (ROS) modulate gene expression and signal transduction pathways in cancer. The book discusses the ways to interfere with the cancer progression, and design of anti-cancer drugs. The book provides an integrated approach for better understanding of the development phases of oxidative stress-induced cancers, and mainly the current perspectives about mechanistic aspects of cancer initiation, progression and metastasis. It is a highly resourceful book and would be extremely important to clinicians, students and researchers in the field of cancer genetics, therapeutics and oncology.

Full Product Details

Author:   Sajal Chakraborti ,  Bimal K. Ray ,  Susanta Roychoudhury
Publisher:   Springer Verlag, Singapore
Imprint:   Springer Verlag, Singapore
Edition:   1st ed. 2022
ISBN:  

9789811594120

ISBN 10:   9811594120
Pages:   2675
Publication Date:   02 February 2022
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Mixed media product
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Involvement of ROS in thyroid cancer Skin cancer induced by pollution-medicated ROS Roles of -Glucans in Oxidative Stress and Cancer Oxidative stress in glioma and its microenvironment Reactive oxygen species and their contribution to carcinogenesis Oral cancer and oxidative stress Oxidative stress in genitourinary cancer Oxidative stress in oral cancer Oxidative stress and glyoxalase pathway in cancer ROS and EMT in multistep carcinogenesis Functional regulation between matrix metalloproteases and cell junction proteins in gastric cancer Association of oxidative stress and mitochondrial dysfunction to gynaecological malignancies Impact of Caenorhabdits elegans in cancdeer drug resistance and development Pharmacology of natural products specifically plant based mitigating cisplatin-induced cardiotoxicity and attenuating oxidative stress, inflammation and associated signalling pathways Scafold based selective ROS generation as viable therapeutic strategies Opportunity for natural and synthetic compounds and stem cell therapy Targeting ROS/RNS for Gliobastoma multiforme treatment strategy Targeting mitochondria as a novel disease modifying therapeutic strategy in Cancer Oxidative stress and cancer: Impact of Yoga and its prevention Cutaneous Oxidative Stress Mediated Endoplasmic Reticulum (ER) Stress and Unfolded Protein Responses (UPR) Iron sulfer clusters and ROS in cancer Biomarkers of Oxidative Stress Identification of oxidative stress targets in cancer Role of apoptotic biomarkars during oxidative stress and cancer Biomarkers of Oxidative Stress and its dynamics in cancer Glutathione as Oxidative stress marker in Cancer Salivary oxidative stress biomarkers in oral potentially malignant disorders and sqamous cell carcinoma Recent Development of Monoclonal Antibodies targeting tyrosine kinase in ROS mediated Cancer Fluoride induced oxidative stress and cancer Role of ROS in chemical carcinogenesis induced by cadmium, lead, chromium and nickel Environmental contaminants and the risk of reproductive cancers Environmental pollutants, oxidative stress and organismal health: Household of three Environmental and occupational contaminants in cancer development Benzo(a)pyrine induced ROS- mediated lung cancer Essential role of occupational hazards in cancer among women New insights on ROS-mediated cellular pathways in solid tumors driven by environmental and occupational carcinogenesis Role of environmental and occupational toxicant in ROS generation and metabolic reprogramming in cancer Apoptosis in cancer cells The Impact of Mitochondrial Fission-Stimulated ROS Production on Pro-Apoptotic Chemotherapy Role of ROS in triggering death receptor-mediated apoptosis Advanced glycation end products mediated oxidative stress and regulated cell death signalling in cancer Helping leukemia cell to die with natural and chemical agents through H2O2signaling Microtube targeting agents induced ROS -mediated apoptosis in cancer ROS induced by chemo and targeted therapy promote apoptosis in cancer cell ROS in apoptosis of cancer cells Induction of apoptosis via Rod signalling pathway Genomic Instability in Carcinogenesis Impact of Environmental and Occupational Exposures in ROS Induced Pancreatic Cancer Reactive oxygen species, central mediators of tumor microenvironment Current trends in biomarkers of oxidative stress induced cancer Reactive Oxygen Species in Male Reproductive Cancers Biomarkers of Oxidative Stress in Cancer, and their Clinical Implications Biofluid markers unveiling cancer diagnosis and prognosis-with special reference to oxidative stress The role of reactive oxygen species on cellular fate/function of tumor infiltrating lymphocytes ROS mediated inflammatory response in cancer Food colors and associated oxidative stress in chemical carcinogenesis Benzo(a)pyrene-induced oxidative stress during lung cancer and treatment with baicalein Role of oxidative stress in orchestrating genomic instability-associated cancer progression Hypoxic stress perturb DNA repair mechanisms leading to genetic instability DNA lesions induced by lipid peroxidation products in cancer progression Understanding ROS induced DNA damage for therapeutics Role of Heavy metals in DNA Damage and Cancer Progression Genotoxicity of ROS induced cancer: Role of natural products Mitochondria metabolism, oxidative stress and the microenvironment in breast cancer development and progression Role of oxidative stress and DNA damage/repair pathways in lung cancer Potential applications of Nrf2 modulators in cancer therapy Relationship between oxidative stress and immune response in cancer Oxidative Stress and Cancer: Role of the Nrf2-Antioxidant Response Element Signaling Pathway Role of Macrophages in Oxidative Stress Induced Inflammatory Tumor Microenvironment The triad,Hypoxia-ROS -Inflammation DNA Damage Response and Oxidative Stress ROS at the intersection of inflammation and immunity in cancer Sestrin 2 connects Autophagy - Gate keepers against tumor progression Insights into the role of cadmium in varcinogenesis via modulating Nrf2 pathway Circadiuacontrol of Nrf2 and SOD1: The nexus of ROS regulation in cancer chronotherapy Chronic inflammation and oxidative stress due to Helicobacter pylori infection contributes to the genesis and perpetuation of gastric cancer New insights into the oxidative stress-induced immune pathogenesis of ovarian cancer Oxidative dyshomeostasis in the mitochondria Role of ROS in tumor progression ROS in cancer metastasis The interdependence of inflammation and ROS in cancer Interplay between oxidative stress and endoplasmic reticulum stress in the metastasis of colon cancer Mitochondria-targeted antioxidants and cancer ROS-mediated genome alterations at cellular microenvironment during cancer metastasis Role of oxidative stress mediated-microRNA alterations in ovarian cancer progression and metastasis Oxidative stress in cancer and its influence on amoeboidal migration Intricacy of ROS in cancer therapy resistance Hypoxia and Oxidative Stress in Progression of Breast Cancer Effect of oxidative stress on autophagy TRP channels, oxidative stress and cancer Wnt signaling in cancer Two-faced role of ROS in the regulation of cancer cell signalling Oxidative Stress and Notch Signaling ROS induced regulatory cross-talk with autoiphagy and Akt Redox regulation of estrogen signalling in human breast cancer ROS impacts on cell cycle checkpoint signalling in carcinogenesis Phosphoinositide -3-kinase/Akt signalling and oxidative stress in cancer Modulation of JAK/STAT Pathways in Cancer by Phytochemicals P62/SQSTM1 -Keap1-Nrf2 pathway - Key regulators in lung cancer ROS-mediated MAP kinase dependent signalling pathway in tumor progression Role of carotenoids on oxidative stress-mediated signaling in cancer cells Cross-talk between oxidative stress and p53 family members in regulating cancer Impact of oxidative stress induced signal transduction in the tumor micro-environment and cancer development. Mutant K-ras mediated oxidative stress in pancreatic cancer Oxidative stress and antioxidant enzymes-coding genes expression in cancer cell models. Regulation of the expression of voltage gated anion channels by noncoding RNA in cancer metastasis mRNA stabilizing factors, new players in cancer progression Redox state and gene regulation in breast cancer Role of a novel ROS generating gene in Uveal Melanoma Administration of siRNA to the targeted site of action in cancer research Role of cigarette smoke in oxidant induced lung cancer Oxidantinduced gene regulation in gastriccancer Oxidative stress induced gene regulation in pancreatic cancer Epigenetic therapy as a potential approach for targeting oxidative stress induced Non small cell lung cancer Free radicals mediated epigenetic changes and breast cancer progression Phytochemicals in ROS-mediated epigenetic regulation of cancer ROS effects on telopmere in cancer Interplay between ROS, noncoding RNAs and cancer Noncoding regulation of redox balance in cancer Epigenetic regulation of micro RNA expression in cancer Oxidized DNA base damage repair and transcription Epigenetic instability caused by oxidative stress can trigger tumorigenesis Oxidative stress and cancer stem cells Metabolims - redox status interplay in tumor stem cells signaling Association of ROS with epithelial-mesenchymal transition and acquisition of stemness during carcinogenesis Therapeutic effect of molecules in targeting ROS induced cancer Therapeutics of Oxidative Stress and Stemness in Breast Cancer Effect of ROS signalling on stem cells Targeting redox signalling and ROS metabolism in cancer treatment Modulatory role of adipocytes and their stem nature in the ROS signalling within a tumor microenvironment Hypoxia induced stress responses in cancer and cancer stem cells Oxidative stress targeted therapies for treatment of leukemia Role of ROS in cancer stem cells: Avenues of interventional therapy Reactive oxygen species dependent signalling pathways in cancer stem cells: Implications in resistance to therapy System Biology and Network Analysis approaches on oxidative stress in cancer Reactive Oxygen Species Mediated Cancer Progression and Metastasis Role of Metabolic Reprogramming in ROS induced anti cancer therapeutics? Na,K-ATPase natural and synthetic inhibitors as anticancer drugs Anthrocyanins and Flavonols Implication of nanomedicine in therapy of oxidative stress induced cancer Metabolic oxidative stress in initiation, progression and therapy of cancer Mitochondrial ROS Oxidative stress and hypoxia in cancer - implications for radiation therapy Oxidative stress in cancer Phytocompounds based approaches Phytoestrogens modulate oxidative stress Prospective applications of natural and synthetic redox modulators in oxidative stress-targeted cancer therapy ROS modulation by iron chelators and synthetic lipids---- a developing anti-cancer strategy ROS, cancer and stem cells Restortive ramnifications of flavonoids and their comjugates in ROS induced cancer Small Molecule Modulators of ROS/NF- BSignaling in Cancer Therapy Targeting hyperglycolysis---oxidative stress apoptosis and by natural ans synthetic compounds in hepatocellulau carcinoma Association of sugary drinks and risk of cancer Bioinformatics application in evaluation of reactive oxidative stress (ROS) and discover patterns in anti-oxidative stress response (AOS) Constraint based reconstruction and analysis for ROS-mediated effects in colon cancer Dynamical methods to study interaction in proteins facilitating molecular understanding of cancer E3 ubiquitin ligases in cancer Insulin resistance and cancer Meprins Molecular analysis of the involvement of IncRNA in cancer development Omics' approach to oxidative stress and cancer: Proteomics and metabolomics in cancer diagnosis and therapy Reactive Oxygen Species induced cancer Systems biology and bioinformatic insights into the role of free radical-mediated oxidative damage in the pathophysiology of cancer Systems biology tools and their clinical applications in cancer therapy The yin and yang of ROS homeostasis and metabolism in cancer Thioredoxin and Glutathione Vitamin C in cancer management: clinical evidence and involvement of redox role Oxidative Stress, Inflammasome and Cancer Preventive role of carotenoids in oxidative stress induced cancer Personalized vaccine as a therapeutic approach towards Cancer Oxidative stress and nutritional status in cancer Enolase: a factor common to cancers and stem cells, yet with divergent function in response to ROS Analytical and omics approaches in the identification of oxidative stress-induced cancer biomarkers Role of ROS in cancer stem cell tumorigenesis, metastasis, and treatment resistance Dynamics of Cobalt Oxide Nanoparticles in activation of ROS linked inflammation and immunomodulation Cancer chemopreventive properties of gallic acid involves mobilization of copper levels and reactive oxygen species generation Nitrogen- and sulfur-containing heterocycles as dual anti-oxidant and anti-cancer agents

Reviews

Author Information

Dr. Sajal Chakraborti is a Professor of Biochemistry in the University of Kalyani, West Bengal, India. His research covers the role of oxidant -mediated signalling in the pathogenesis of a variety of diseases. Prof. Chakraborti did is PhD from Calcutta University (1982) and D.Sc from Kalyani University (2004). He did post doctoral research at the Johns Hopkins University, Baltimore; University of Utah Health Sciences Center, Salt Lake City and New York Medical College, New York as a Fulbright Fellow. He received DBT (Govt. of India)-senior overseas research award for his research at the University of Florida, Gainesville (1998-1999). He has been engaged in teaching and research in biochemistry for the past 40 years. He has published over 110 original research papers, 22 book chapters and 15 review articles. He also edited 12 books (Springer). Dr. Bimal K Ray is a Professor of Pathology of the University of Missouri, Columbia, Missouri, USA. He has more than 40 years of teaching and research experience in different universities in USA. One of his research interests is the understanding the basic mechanisms associated with inflammation, the consequence of which is linked to abnormal gene expression that may lead to cancer. Recent findings of Dr. Ray's laboratory suggest that serum amyloid A-activating factor-1 (SAF-1) activates superoxide dismutase and few other reactive species sensitive antioxidant enzymes in breast cancer and thereby allowing cancer cell proliferation. Dr. Ray published over 100 original research papers and review articles in different international journals of repute. He also published several chapters in books published by reputed publishers. Dr. Susanta Roychoudhury obtained his Ph.D degree from Calcutta University in 1985. He did postdoctoral research at the University of Pennsylvania, USA (1985 to 1990). After that he joined the CSIR-Indian Institute of Chemical Biology, Kolkata, India as a scientist (1991-2015). Subsequently, he was associated with Saroj Gupta Cancer Centre & Research Institute, Kolkata, India as Chief of Basic Research (2015-2021). Currently, he is the ICMR Emeritus Scientist at CSIR-Indian Institute of Chemical Biology, Kolkata, India. As a cancer geneticist, Dr. Roychoudhury made significant contributions on the molecular understanding of the genomic instabilities and functional consequences of gain-of function mutations of TP53 gene in human cancer. He has contributed in the area of cancer stem cells using oral cancer model and developed a microarray-based gene expression signature that distinguishes the aggressive subset of early stage oral cancer from non-aggressive one. He has published over 150 original research articles in several international journals of repute and several review articles and book chapters. Dr. Roychoudhury is the Fellow of all the three Science Academies of India. He has been elected as President of Indian Association for Cancer Research in 2016 and is a recipient of Sir J C Bose National Fellowship by Department of Science and Technology, Govt. of India in 2017.

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