Overview

This volume contains data on multiple immunomodulators, many of which are also the products of hypothalamic brain cell neurosecretion. Interleukins (IL-1a, IL-1ß, IL-2, IL-4, IL-6, TNFa), immunophylin and ubiquitin as well as proline rich peptides, comprised of 10-15 amino acids are being produced in N. Supraopticus and N. Paraventricularis and then secreted into neurohypophysis. Along the neurosecretion of the mentioned cytokines, there are other immunomodulators, the primary structure of which had been completely deciphered such as: Immunophyllins, intracellular receptors of immunosuppressors FK506, cyclosporine A., rapamicin. They are peptidyl-prolyl-cis-trans-isomerases. There are novel immunological hypothalamic factors such as ubiquitin, macrophage migration inhibitory factor (MIF), as well as Thymosin ß 4(1-39). This data allowed us to propose the concept of neuroendocrine immune system of the brain.

Full Product Details

Author:   Armen Galoyan ,  Abel Lajtha ,  Hugo Besedovsky
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   3rd ed. 2008
Dimensions:   Width: 17.00cm , Height: 2.50cm , Length: 24.40cm
Weight:   1.056kg
ISBN:  

9780387303581

ISBN 10:   0387303588
Pages:   495
Publication Date:   14 December 2007
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

BRAIN CYTOKINES AS INTEGRATORS OF THE IMMUNE-NEUROENDOCRINE NETWORK – H. O. Besedovsky and A. del Rey.- NEUROPEPTIDES IN THE IMMUNE SYSTEM: MEDIATORS OF STRESS AND INFLAMMATION – D.S. Jessop.- EFFECTS OF THE IMMUNE SYSTEM ON BRAIN NEUROCHEMISTRY – A. J. Dunn.- AGE-RELATED ALTERATIONS IN AUTONOMIC NERVOUS SYSTEM INNERVATION OF LYMPHOID TISSUE – D. L. Bellinger, C. L. Lubahn, A. B. Millar, J. L. Carter, S. Vyas, S. D. Perez, and D. Lorton.- DRUGS THAT TARGET SYMPATHETIC-IMMUNE PATHWAYS FOR TREATMENT OF AUTOIMMUNE DISEASES – D. Lorton, C. Lubahn, and D. Bellinger.- NEURO-IMMUNE ASSOCIATIVE LEARNING – M.-B. Niemi, G. Pacheco-López, H. Engler, C. Riether, R. Doenlen, and M. Schedlowski.- THE BRAIN IMMUNE SYSTEM: CHEMISTRY AND BIOLOGY OF SIGNAL MOLECULES – A. Galoyan.- THE DIALECT OF IMMUNE SYSTEM IN THE CNS: THE NERVOUS TISSUE AS IMMUNE  COMPARTMENT FOR T CELLS AND DENDRITIC CELLS – Z. Fabry, E. Reinke, A. Zozulya, M. Sandor, and I. Bechmann.- IMMUNOPROTEASOME ACTIVITY IN THE NERVOUS SYSTEM – M. T. Rinaudo and M. Piccinini.- REGULATION OF THE INFLAMMATORY RESPONSE IN BRAIN – W. Stenzel and G. Alber.- EVOLUTIONARY ORIGINS OF THE BRAIN'S IMMUNE PRIVILEGE. IMPLICATIONS FOR NOVEL THERAPEUTIC APPROACHES: GENE THERAPY – P. R. Lowenstein, K. Kroeger, C. Barcia, J. Zirger, D. Larocque, and M. G. Castro.- ADENOSINE: AN ENDOGENOUS REGULATOR OF THE BRAIN IMMUNE SYSTEM – G. Haskó and E. S. Vizi.- NEUROIMMUNE CROSS TALK – G. Juhász.- ROLE OF GLIA IN CNS INFLAMMATION – S. Pawate and N. R. Bhat.- AUTOIMMUNE PROCESSES IN THE CENTRAL NERVOUS SYSTEM – C. J. Welsh and C. R. Young.- EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS – B. Gran, K. O’Brian, D. Fitzgerald, and A. Rostami.- IMMUNOLOGICAL ASPECTS OF CENTRAL NERVOUS SYSTEM DEMYELINATION – S. Pawate and S. Sriram.- THE INFLAMMATORY COMPONENT OF NEURODEGENERATIVE DISEASES – C. C. Ferrari and F. J. Pitossi.- MECHANISMS OF INFLAMMATION IN HIV-ASSOCIATEDDEMENTIA – B. Giunta, F. Fernandez, and J. Tan.- ROLE OF POLY(ADP-RIBOSE) POLYMERASE IN BRAIN INFLAMMATION AND NEUROINJURY – G. S. Scott, K. Komjáti, V. C. Besson, and C. Szabó.- SCHIZOPHRENIA AND IMMUNE RESPONSES – F. Gaughran, J. Welch

Reviews

From the reviews of the third edition: A new edition of the Handbook of Neurochemistry and Molecular Neurobiology has now been issued in 25 volumes. It contains fundamental data on current molecular neurobiology, neuroimmunology, and neuropathology. This is the first time that the series contain Neuroimmunology, which summarizes achievements in neurochemistry, neuroendocrinology, neurophysiology, and the pathology of the nervous system. This book presents research performed by scientists in various countries. a handbook for scientists, students, and clinicians. (K. G. Gevorgyan, Neurochemical Journal, Vol. 3 (1), 2009)

From the reviews of the third edition: ""A new edition of the Handbook of Neurochemistry and Molecular Neurobiology has now been issued in 25 volumes. It contains fundamental data on current molecular neurobiology, neuroimmunology, and neuropathology. This is the first time that the series contain Neuroimmunology, which summarizes achievements in neurochemistry, neuroendocrinology, neurophysiology, and the pathology of the nervous system. … This book presents research performed by scientists in various countries. … a handbook for scientists, students, and clinicians."" (K. G. Gevorgyan, Neurochemical Journal, Vol. 3 (1), 2009)

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