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Full Product Details

Author:   Simon E Ward (Cardiff University, UK) ,  Andrew Davis (AstraZeneca, Sweden)
Publisher:   Royal Society of Chemistry
Imprint:   Royal Society of Chemistry
Edition:   2nd edition
Weight:   4.578kg
ISBN:  

9781788018982

ISBN 10:   1788018982
Pages:   1050
Publication Date:   03 February 2023
Audience:   College/higher education ,  Professional and scholarly ,  Tertiary & Higher Education ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Physicochemical Properties; Synthesis in Medicinal Chemistry; Useful Computational Chemistry Tools for Medicinal Chemistry; Structure-based Design for Medicinal Chemists; Fragment-based Ligand Discovery; Machine Learning in Drug Design; Drug Metabolism; ADME Optimization in Drug Discovery; Molecular Biology for Medicinal Chemists; Assays; In Vitro Biology: Measuring Pharmacological Activity That Will Translate to Clinical Efficacy; Animal Models: Practical Use and Considerations; Bioinformatics for Medicinal Chemistry; Translational Science; Discovery Toxicology in Lead Optimization; Toxicology and Drug Development; Patents for Medicines; Target Validation for Medicinal Chemists; Lead Optimisation: What you should know!; Pharmaceutical Properties – The Importance of Solid Form Selection; The Medicinal Chemistry and Process Chemistry Interface; Clinical Drug Development; SMN2 Splicing Modification by Small Molecules – A Blueprint to Tackle the Underlying Genetic Cause of Many Underserved Diseases; The Discovery of Checkpoint Kinase 1 Inhibitors: From Fragments to Clinical Candidate; Medicinal Chemistry for Neglected Diseases – Malaria, Tuberculosis, Sleeping Sickness, Leishmaniasis and River Blindness; New Therapeutic Chemical Modalities: Compositions, Modes-of-action, and Drug Discovery

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