Overview

This unique book provides comprehensive overview of the field of immunology related to engineered nanomaterials used for biomedical applications. It contains literature review, case studies and protocols. The book can serve as a source of information about nanoimmunotoxicology for both junior scientists and experts in the field. The authors have more than 10 years of experience with preclinical characterization of engineered nanomaterials used for medical applications, and they share their experience with the readers. In addition, the international team of experts in the field provides the opinion and share the expertise on individual topics related to nanoparticle physicochemical characterization, hematocompatibility, and effects on the immune cell function . The second edition contains updated chapters from the first edition plus new chapters covering areas of tumor immunology, nanoparticle interaction with lymphatic system, mathematical modeling of protein corona, utilization of nanoparticles for the delivery of antiviral drugs, extensive analysis of nanoparticle anti-inflammatory and immunosuppressive properties, novel ways of protecting therapeutic nanoparticles from the immune recognition, as well as case studies regarding nanoparticle sterilization, complement activation, protein binding and immunotherapy of cancer. The second edition comes in 3 volumes. Volume 1 is focused on nanoparticle characterization, sterility and sterilization, pyrogen contamination and depyrigenation. It also contains overview of regulatory guidelines, protocols for in vitro and in vivo immunotoxicity studies, and correlation between in vitro and in vivo immunoassays. Volume 2 is focused on hematocompatibility of nanomaterials. It provides comprehensive review and protocols for investigating nanoparticle interaction with erythrocytes, platelets, endothelial cells, plasma coagulation factors and plasma proteins forming so called 'corona' around nanoparticles. Volume 3 is dedicated to nanoparticle interaction with and effects on the immune cell function. It also contains examples of nanoparticle use for delivery of antiviral and anti-inflammatory drugs.

Full Product Details

Author:   Marina A Dobrovolskaia (Leidos Biomedical Research Inc., Usa) ,  Scott E Mcneil (Leidos Biomedical Research Inc., Usa)
Publisher:   World Scientific Publishing Co Pte Ltd
Imprint:   World Scientific Publishing Co Pte Ltd
Edition:   Second Edition
Volume:   6
Dimensions:   Width: 17.50cm , Height: 6.60cm , Length: 25.70cm
Weight:   2.744kg
ISBN:  

9789814699167

ISBN 10:   9814699160
Pages:   1184
Publication Date:   16 April 2016
Audience:   College/higher education ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

Volume 1: Key Considerations for Nanoparticle Characterization Prior to Immunotoxicity Studies: Immunological Properties of Engineered Nanomaterials: An Introduction (Dobrovolskaia MA & Mcneil SE); Importance of Physicochemical Characterization Prior to Immunological Studies (Clogston JD & Patri AK); Nanoparticle Sterility and Sterilization of Nanomaterials (Subbarao N); Sterilization Case Study 1: Consequences of Different Sterilization Techniques on Gold Nanoparticles (Gonzalez-Fernandez A et al.); Sterilization Case Study 2: Effects of Sterilization Techniques on Silver Nanoparticles (Dobrovolskaia MA et al.); Surface Contaminants and Their Role in Nanoparticle Immunotoxicity (Grainger D et al.); Endotoxin and Engineered Nanomaterials (Dobrovolskaia MA & Mcneil SE); Endotoxin Case Study: Nanoparticle Interference with Gel-Clot LAL (Kraegeloh A et al.); Regulatory Considerations (Weaver J. et al.); In Vitro Assays to Monitor Nanoparticle Interaction with Components of the Immune System (Dobrovolskaia MA & Mcneil SE); Animal Models to Monitor Adverse Effects of Nanomaterials on the Immune System (Smith M et al.); Understanding Correlation Between In Vitro and In Vivo Immunological Assays for Engineered Nanomaterials (Dobrovolskaia MA & Mcneil SE); Volume 2: Haematocompatibility of Engineered Nanomaterials: Interaction with Plasma Proteins as It Relates to Particle Biodistribution (Nienhaus U and Treuel L); Protein Binding Case Study 1: Understanding Relationship Between Protein Corona and Nanoparticle Toxicity (Dobrovolskaia M et al.); Mathematical Modeling of Protein Corona and Its Implication in the Design of Nanotechnology-Based Drug Delivery Systems (Cedervall T); Effects on Erythrocytes (Brown R et al.); Effects on Endothelial Cells (Simak J); Effects on Plasma Coagulation (Simak J); Effects on Platelets (Simak J); Nanoparticles and Coagulation System: Benefits of Nanotechnology and Safety Considerations (Ilinskaya A & Dobrovolskaia M A); Complement Activation by Nanomaterials (Salvador-Morales C & Sim R); Complement Activation Case Study: Induction of CARPA by PEGylated Liposomes (Szebeni J et al.); Nanoparticles and the Lymphatic System (Khan W and Sistla); Volume 3: Engineered Nanomaterials and the Immune Cell Function: Bidirectional Interaction Between Nanoparticles and Cells of the Mononuclear Phagocytic System (Zamboni W et al.); Case Study: Application of Leukolike Technology to Camouflage Nanoparticles from the Immune Recognitiont (Tasciotti E et al.); The Effects of Nanoparticles on Dendritic Cells (Fesenkova V); The Effects of Nanoparticles on Bone Marrow Cells (Dadacheva E); Nanoparticles and Vaccine Delivery and Efficacy (Xiang S et al.); Undesirable Adjuvanticity of Nanoparticles and Its Implication in Modulation of T Helper Responses (Inoue K); Immunosuppressive and Anti-Inflammatory Properties of Engineered Nanomaterials (Ilinskaya A & Dobrovolskaia MA); Nanoparticles as Drug Deliveyr Vehicels for the Therapy of Inflammatory Disorders (Menon D et al.); Application of Nanoparticles for the Delivery of Anti-Viral Drugs (Liptrott N et al.); Nanostructures and Allergy (Lorenzo-Abalde S & Gonzalez-Fernandez A); Nanoparticles and Antigenicity (Dobrovolskaia MA); Nanoparticles and Tumor Immunity Case Study: Application of Iron Oxide Nanoparticle to CD8+ T Cell Response Against Primary Response Against Primary and Secondary Tumors Through Induction of Local Hyperthermia (Fiering S et al.);

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