Overview

Growth factors are extracellular signalling substances that are secreted by a wide diversity of cell types and are involved in the regulation of cell proliferation and differentiation. They have an important role to play in normal physiological processes such as tissue development and regeneration and also in abnormal cellular proliferations such as those associated with malignant diseases. Part of a three-volume set, this volume is devoted to haematopoiesis and its regulation by endogenous factors with growth stimulatory and growth inhibitory properties. The book provides detailed discussions of signalling agents related to the regulations of haematopoiesis, including the interleukins, the colony-stimulating factors, the interferons, the tumour necrosis factors, the erythropoietic growth factors and the platelet-derived. The structure and function of each factor is covered in detail, as well as its receptor and postreceptor mechanism of action and its possible role in neoplastic processes.

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9780849325076

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