Overview

Dyneins are molecular motors that are involved in various cellular processes, such as cilia and flagella motility, vesicular transport, and mitosis. Since the first edition of this book was published in 2012, there has been a significant breakthrough: the crystal structures of the motor domains of cytoplasmic dynein have been solved and the previously unknown details of this huge and complex molecule have been unveiled. This new edition contains 14 chapters written by researchers in the US, Europe, and Asia, including 3 new chapters that incorporate new fields. The other chapters have also been substantially updated. Compared with the earlier edition, this book focuses more on the motile mechanisms of dynein, especially by biophysical methods such as cryo-EM, X-ray crystallography, and single-molecule nanometry. It is a major handbook for frontline researchers as well as for advanced students studying cell biology, molecular biology, biochemistry, biophysics, and structural biology.

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9789814800013

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Reviews

Given the recent explosion of interest in dynein, this book gives a timely review of both historical and current developments in the field. It is an extensive compendium compiled by leading dynein researchers and an excellent resource for young and experienced scientists alike! Prof. Joe Howard - Max Planck Institute of Molecular Cell Biology and Genetics, Germany Handbook of Dynein, edited by the eminent electron microscopists Keiko Hirose and Linda Amos and contributed to by many international leading scientists in the field, is an excellent introduction to cutting-edge dynein research, including such aspects as biochemistry, molecular biology, biophysics, structural biology, and molecular genetics. It introduces not only the mechanisms of how cilia and flagella move and how the intracellular transport is performed by dyneins but also the pathogenesis of diseases related to the dynein motor complex. Thus, it will be a really fine handbook for students and researchers in the broad areas of life sciences. Prof. Nobutaka Hirokawa - University of Tokyo, Japan

Given the recent explosion of interest in dynein, this book gives a timely review of both historical and current developments in the field. It is an extensive compendium compiled by leading dynein researchers and an excellent resource for young and experienced scientists alike! Prof. Joe Howard - Max Planck Institute of Molecular Cell Biology and Genetics, Germany Handbook of Dynein, edited by the eminent electron microscopists Keiko Hirose and Linda Amos and contributed to by many international leading scientists in the field, is an excellent introduction to cutting-edge dynein research, including such aspects as biochemistry, molecular biology, biophysics, structural biology, and molecular genetics. It introduces not only the mechanisms of how cilia and flagella move and how the intracellular transport is performed by dyneins but also the pathogenesis of diseases related to the dynein motor complex. Thus, it will be a really fine handbook for students and researchers in the broad areas of life sciences. Prof. Nobutaka Hirokawa - University of Tokyo, Japan

Author Information

Keiko Hirose is a researcher with more than 30 years’ experience in structural and functional studies of motor proteins. She has a PhD from the University of Tokyo and was a postdoctoral fellow at the University of Pennsylvania and at the MRC Laboratory of Molecular Biology, Cambridge, UK. She is especially interested in how molecular motor proteins, such as dynein, move. Dr. Hirose has been working at the National Institute of Advanced Industrial Science and Technology, Japan, since 1997.

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