Handbook of Chemical Glycosylation: Advances in Stereoselectivity and Therapeutic Relevance

Author:   Alexei V. Demchenko (University of Missouri, USA)
Publisher:   Wiley-VCH Verlag GmbH
ISBN:  

9783527317806


Pages:   524
Publication Date:   20 February 2008
Format:   Hardback
Availability:   To order   Availability explained
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Handbook of Chemical Glycosylation: Advances in Stereoselectivity and Therapeutic Relevance


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Overview

Since carbohydrate oligomers are still a challenge in synthetic chemistry, this book on recent developments fulfils a great need. Covering the chemistry necessary to synthesize exact copies of these structures, top authors from all around the world comprehensively deal with synthesis from anomeric halides, from miscellaneous glycosyl donors, and by indirect and special methods, as well as 1-oxygen-and 1-sulfur-substituted derivatives. They demonstrate the best approach for the stereoselective formation of the intermonomeric bond, making this essential reading for every biochemist working in biosynthesis, the exploration of biopathways and vaccines.

Full Product Details

Author:   Alexei V. Demchenko (University of Missouri, USA)
Publisher:   Wiley-VCH Verlag GmbH
Imprint:   Blackwell Verlag GmbH
Dimensions:   Width: 18.20cm , Height: 3.10cm , Length: 24.60cm
Weight:   1.116kg
ISBN:  

9783527317806


ISBN 10:   3527317805
Pages:   524
Publication Date:   20 February 2008
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   To order   Availability explained
Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us.

Table of Contents

GENERAL ASPECTS OF THE GLYCOSIDIC BOND FORMATION GLYCOSIDE SYNTHESIS FROM ANOMERIC HALIDES Glycosyl Fluorides Glycosyl Chlorides, Bromides, and Iodides GLYCOSIDE SYNTHESIS FROM 1-OXYGEN-SUBSTITUTED GLYCOSYL DONORS Hemiacetals and O-Acyl/Carbonyl Derivatives Glycosyl Imidates Anomeric Transglycosylation Phosphites, Phosphates, and Other O--P Derivatives GLYCOSIDE SYNTHESIS FROM 1-SULFUR/SELENIUM-SUBSTITUTED DERIVATIVES Thioalkyl and Thioaryl Glycosides Sulfoxides, Sulfimides, and Sulfones Xanthates, Thioimidates, and Other Thio Derivatives Selenoglycosides OTHER METHODS FOR GLYCOSIDE SYNTHESIS Orthoesters and Related Derivatives Dehydro and Anhydro Derivatives Miscellaneous Glycosyl Donors Indirect and Special Methods

Reviews

I recommend this monograph to all those who deal with carbohydrate chemistry or wish to do so. (Angewandte Chemie, July 7, 2008) An excellent compilation of chemical glycosylation methods...I read this book with great pleasure...I recommend this monograph to all those who deal with carbohydrate chemistry... (Angewandte Chemie, 29/2008)


I recommend this monograph to all those who deal with carbohydrate chemistry or wish to do so. (Angewandte Chemie, July 7, 2008) An excellent compilation of chemical glycosylation methods...I read this book with great pleasure...I recommend this monograph to all those who deal with carbohydrate chemistry... (Angewandte Chemie, 29/2008)


Author Information

Born in 1965, Alexei Demchenko gained his MSc in chemical engineering from Mendeleev University of Chemical Technology, Russia, in 1988, before joining the Zelinski Institute of Organic Chemistry, at the Russian Academy of Sciences, Moscow. It was here, under Professor Kochetkov, that he took his first steps in researching carbohydrate synthesis. In 1993 he was awarded a PhD for his work on the development of thiocyanate methodology for stereospecific glycosylation and, after two post-doctoral years under Kochetkov, he joined Geert-Jan Boons' group at the University of Birmingham, UK, as a BBSRC post-doctoral research fellow. In 1998 he moved with Professor Boons to the Complex Carbohydrate Research Center at the University of Georgia as a research associate, where his research focused on the synthesis of complex oligosaccharides for immunological studies and the exploration of chemical O-sialylation. In 2001 he joined the University of Missouri St. Louis as an assistant professor of chemistry and biochemistry. Professor Demchenko is a recipient of the CAREER award from the National Science Foundation, and has co-authored over 50 articles, reviews, and book chapters. His current research interests are in the field of synthetic carbohydrate chemistry.

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