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Author:   John Burthem ,  John C. Cawley
Publisher:   Springer London Ltd
Imprint:   Springer London Ltd
Edition:   Softcover reprint of the original 1st ed. 1996
Dimensions:   Width: 15.50cm , Height: 0.70cm , Length: 23.50cm
Weight:   0.207kg
ISBN:  

9781447112563

ISBN 10:   1447112563
Pages:   111
Publication Date:   06 October 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1 Introduction and Historical Aspects.- 2 Clinical Aspects.- 2.1 Clinical features.- 2.1.1 Epidemiology.- 2.1.2 Clinical features.- 2.2 Laboratory features.- 2.2.1 Haematology.- 2.2.2 Other clinical laboratory investigations.- 2.3 Prognosis: staging systems.- 3 Pathology.- 3.1 Bone marrow.- 3.2 Spleen.- 3.3 Liver.- 3.4 Lymph nodes.- 3.5 Other blood cells.- 3.5.1 Monocytes.- 3.5.2 T cells.- 3.5.3 Other haemic cells.- 3.6 Viruses and HCL.- 4 Diagnosis and Hairy-like Disorders.- 4.1 The diagnosis of typical HCL.- 4.2 Diagnosis when few abnormal cells are present.- 4.3 Diagnosis of HCL in the presence of atypical clinical or pathological features.- 4.4 Variant forms of HCL and closely related conditions.- 4.5 Atypical and rare presentations.- 5 Treatment: Mechanisms.- 5.1 Mechanism of action of splenectomy.- 5.2 The mechanism of action of ?IFN.- 5.2.1 Indirect effects.- 5.2.2 ‘Direct’ anti-proliferative activity.- 5.2.3 Modification of intracellular signals by ?IFN.- 5.2.4 Altered differentiation/activation state.- 5.3 Mechanism of action of the purine analogue drugs.- 5.3.1 Normal purine metabolism in lymphoid cells: the role of adenosine deaminase.- 5.3.2 Adenosine deaminase function in the presence of purine analogue drugs.- 5.3.3 Action of purine analogue drugs on malignant cells.- 6 Treatment: Practical Considerations.- 6.1 When should treatment be commenced?.- 6.2 Splenectomy.- 6.2.1 Therapeutic value of splenectomy.- 6.3 Interferon.- 6.3.1 Therapeutic activity of IFN in HCL.- 6.3.2 Problems with IFN therapy.- 6.3.3 Alternative strategies.- 6.4 Purine analogue drugs: DCF, CDA and fludarabine.- 6.4.1 Therapeutic activity of DCF.- 6.4.2 Therapeutic activity of CDA.- 6.4.3 Fludarabine.- 6.4.4 Choice of purine analogue drug in HCL.- 6.5 The use of colony-stimulating factors in HCL.- 6.6 Overview of therapeutic options.- 6.7 Treatment after failure of primary treatment option.- 6.8 Other treatment options.- 7 The Hairy Cell.- 7.1 Cytology.- 7.2 Cytochemistry.- 7.2.1 Tartrate-resistant acid phosphatase (TRAP).- 7.2.2 Other cytochemical techniques.- 7.3 Cytogenetics.- 7.3.1 Frequency of karyotypic abnormalities.- 7.3.2 Specificity of chromosomal changes.- 7.3.3 Possible significance of karyotypic changes in HCL.- 7.4 Ultrastructure.- 7.4.1 Transmission electron microscopy.- 7.4.2 Scanning electron microscopy.- 7.5 Nature of the malignant cell.- 7.5.1 Developmental stage: evidence from immunoglobulin studies.- 7.5.2 Developmental stage: evidence from immunophenotypic studies.- 7.5.3 Developmental stage: other approaches.- 7.6 Membrane, cytoskeletal organisation and signalling.- 7.6.1 Membrane.- 7.6.2 Cytoskeleton.- 7.6.3 Signalling.- 7.7 Response to cytokines.- 7.7.1 Low molecular weight B-cell growth factor.- 7.7.2 Tumour necrosis factor.- 7.7.3 Interleukin-2.- 7.7.4 Other interleukins.- 7.7.5 Myeloid growth factors.- 7.8 Adhesion and tissue localisation.- 7.8.1 Non-integrin adhesion receptors.- 7.8.2 Integrins.- 7.8.3 Adhesion molecules and HC behaviour.- 7.9 Cell survival and cell death.- Appendices.- Appendix A: Tartrate-resistant acid phosphatase (TRAP).- Appendix B: CD-antigen expression by HCs.- References.

Reviews

"""This excellent little book brings together a lot of the knowledge obtained in the last 40 years and I enjoyed reading it...I have no hesitation in recommending this book. It is well written, authoritative and practical. All haematologists should have access to it."" Cancer Forum"

""This excellent little book brings together a lot of the knowledge obtained in the last 40 years and I enjoyed reading it...I have no hesitation in recommending this book. It is well written, authoritative and practical. All haematologists should have access to it."" Cancer Forum

This excellent little book brings together a lot of the knowledge obtained in the last 40 years and I enjoyed reading it...I have no hesitation in recommending this book. It is well written, authoritative and practical. All haematologists should have access to it. Cancer Forum

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