Overview

This volume explores the basic physiological functions of granulocytes, their modification by cytokines, and the clinical experience with cytokines - discussing the specific responses of neutrophils, eosinophils, basophils, and mast cells to individual cytokines. Written by more than 60 experts from all over the world, Granulocyte Responses to Cytokines ... : examines the responses of granulocytes and mast cells to hormones, chemotactic peptides, and phorbol esters; details cytokine effects on morphology, micration, adhesion, phagocytosis, degranulation, and cytotoxicity against tumour cells and pathogens; covers cyclic nucleotide, protein kinases, G proteins, lipoxygenase, and leukotrienes in the regulation of granulocyte functions; indicates caution in the use of cytokine therapy for certain leukaemias due to cytokine effects on the growth of malignant cells; and presents clinical studies with granulocyte-macrophage and granulocyte colony-stimulating factors with promising results in treating genetic, virus-, and drug-induced granulocytopenias and immunodeficiencies. Containing nearly 3900 literature citations, Granulocyte Responses to Cytokines is a guide for immunologists; hematologists; oncologists; pharmacologists; biologists, microbiologists, and biochemists; pathologists; internists; and graduate-level students in these disciplines.

Full Product Details

Author:   Ronald G. Coffey
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Volume:   57
Dimensions:   Width: 21.60cm , Height: 4.10cm , Length: 27.90cm
Weight:   1.406kg
ISBN:  

9780824786557

ISBN 10:   0824786556
Pages:   736
Publication Date:   22 July 1992
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

Functions of granulocytes - neutrophil activation and function in health and disease, Kent J. Johnson, et al, the neutrophil respiratory burst mechanisms, Linda C. McPhail, et al, regulation of lipoxygenase enzymes in leukocytes, Jack Y. Vanderhoek, activation of leukotriene production in granulocytes - effects on cell activation, Anthony W. Ford-Hutchinson, G-proteins and the role of second messengers in the regulation of the human neurophil, Pramod M. Lad, et al; eosinophil activation and function in health and disease, Randa I. Abu-Ghazaleh, et al, basophils and mast cells - piecemeal degranulation in situ and ex vivo - a possible mechanism for cytokine-induced function in disease, Ann M. Dvorak, signal mechanisms in the activation of basophils and mast cells, Donald MacGlashan, Jr, effects of cyclic nucleotides on granulocytes, Ronald G. Coffey; effects of cytokines - basic research - regulatory effects of cytokines on myeolopoi8esis, F. Herrmann and R. Mertelsmann, cytokine-stimulated emigration of granulocytes in vivo, Dennis E. Van Epps, physiological studies with human leukocyte inhibitory factor, Larry Borish and Ross Rocklin, the biology of NAP-1/IL-8, a neutrophil-activating cytokine, Jens-M. Schroder and Enno Christophers, activation of neurophils by interleukins-1 and -2 and tumour necrosis factors, Antonio Ferrante, modulation of neurophil functions by y-interferon, Giorgio Berton and Marco A. Cassatella, activation of neurophils by granulocyte-macrophage colony-stimulating factor, John F. DiPersio and Camille N. Abboud, biochemical effects of human granulocyte-macrophage colony-stimulating factor (GM-CSF) on the human neurophil, Richard Sullivan, mechanisms of host tissue damage by cytokine-activated neurophils, Antonio Ferrante, et al, tumour necrosis factor stimulation of neutrophils for antitumour activity, Hunghyi Shau and Robert L. Roberts, interferon activiation oeosinophils, C. De Simone, et al, regulation of human eosinophil production and function by interleukin-5,Angel F. Lopez, et al, cytokine stimulation of human basophil histamine releas, Mary Haak-Frendscho and Allen P. Kaplan, hemopoietic growth factors regulate basophil function and viability, Koichi Hirai, et al, effects of hematopoietic growth factors on nonhematopoietic cells, Shoukat Dedhar and Connie Eaves, effects of cytokines on the expression of adhesion molecules in allergic diseases, Eduardo Calderon; effects of cytokines - clinical research - granulocyte colony-stimulating factors as therapeutic agents, Robert E. Donahue and Steven C. Clark, G-CSF and M-CSF - preclinical and clinical results, F. Herrmann, et al, clinical trials of granulocyte-macrophage colony-stimulating factor for the treatment of aplastic anemia, Saroj Vadhan-Raj, clinical trials of granulocyte colony-stimulating fractors for treatment of bone marrow depression associated with cancer chemotherapy, Graham J. Lieschke and George Morstyn.

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