Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
Author:   Raphael Enoque Ferraz de Paiva
Publisher:   Springer Nature Switzerland AG
Edition:   1st ed. 2018
ISBN:  

9783030008529


Pages:   151
Publication Date:   11 October 2018
Format:   Hardback
Availability:   Manufactured on demand   Availability explained
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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins


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Overview

This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.

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Author:   Raphael Enoque Ferraz de Paiva
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
Edition:   1st ed. 2018
Weight:   0.459kg
ISBN:  

9783030008529


ISBN 10:   3030008525
Pages:   151
Publication Date:   11 October 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

"Au(I)-phosphine series design.- Probing the Protein: Ion Mobility Spectrometry.- Probing Gold: X-ray Absorption Spectroscopy.- Probing Cells: Cytotoxicity Evaluation.- Au(III) series with k2C,N and k2N,N' ligands.- ""Dual Probe"" X-ray Absorption Spectroscopy."

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