Overview

The most trusted, rigorous, and up-to-date toxicology resource and educational companion available – now in full color A Doody's Core Title ESSENTIAL PURCHASE for 2011! Goldfrank’s Toxicologic Emergencies continues to be the source you can turn to first for any poisoning or overdose. The text provides clear information on every aspect of toxicologic emergencies, from pharmacology to clinical presentation to management. Fully referenced and featuring a consistent organization, Goldfrank’s begins with an in-depth examination of general principles of medical toxicology. It then progresses to the biochemical principles and molecular basis of toxicology, and provides detailed insight into how xenobiotics affect vital signs, organs, and systems throughout the body. Next, a wide spectrum of clinically important exposures -- including drugs, plants, metals, household products, occupational and environmental xenobiotics are covered within logical categories for easy access to information. Finally, the book concludes with sections on principles of practicing clinical toxicology in today’s challenging healthcare environment. NEW TO THIS EDITION Full-color design and uniformly drawn figures clarify key conceptsSpecial Considerations focus on decision-making in unique toxicologic circumstances, that influence clinical practice and have the potential to improve patient care Antidotes in Depth, following pertinent chapters, place each antidote in its proper context to ensure immediate availability of essential information relevant for clinical useMore clinically-relevant figures and quick-reference tables Online learning center, available at www.goldfrankstoxicology.com, includes case studies, and a database of multiple choice questions that allow you to create a custom test for review and study. Every chapter is thoroughly rewritten and new chapters are added to reflect the very latest thinking in the field

Full Product Details

Author:   Lewis Nelson ,  Neal Lewin ,  Mary Ann Howland ,  Robert Hoffman
Publisher:   McGraw-Hill Education - Europe
Imprint:   McGraw-Hill Medical
Edition:   9th edition
Dimensions:   Width: 22.40cm , Height: 7.10cm , Length: 28.50cm
Weight:   4.217kg
ISBN:  

9780071605939

ISBN 10:   0071605932
Pages:   1968
Publication Date:   16 September 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   In Print  
Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock.

Table of Contents

Table of Antidotes in Depth Contributors Preface Acknowledgments 1. Historical Principles and Perspectives, Paul M. Wax 2. Toxicologic Plagues and Disasters in History, Paul M. Wax PART A: THE GENERAL APPROACH TO MEDICAL TOXICOLOGY 3. Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes, Lewis S. Nelson, Neal A. Lewin, Mary Ann Howland, Robert S. Hoffman, Lewis R. Goldfrank, and Neal F. Flomenbaum 4. Principles of Managing the Acutely Poisoned or Overdosed Patient, Lewis S. Nelson, Neal A. Lewin, Mary Ann Howland, Robert S. Hoffman, Lewis R. Goldfrank, and Neal F. Flomenbaum 5. Diagnostic Imaging, David T. Schwartz 6. Laboratory Principles, Petrie M. Rainey 7. Techniques Used to Prevent Gastrointestinal Absorption, Anne-Bolette J. Christophersen and Lotte C.G. Hoegberg A1. Syrup of Ipecac, Mary Ann Howland A2. Activated Charcoal, Mary Ann Howland A3. Whole-Bowel Irrigation and Other Intestinal Evacuants, Mary Ann Howland 8. Pharmacokinetic and Toxicokinetic Principles, Mary Ann Howland 9. Principles and Techniques Applied to Enhance Elimination, David S. Goldfarb 10. Use of The Intensive Care Unit, Mark A. Kirk PART B: THE FUNDAMENTAL PRINCIPLES OF MEDICAL TOXICOLOGY Section 1: Biochemical and Molecular Basis 11. Chemical Principles, Stephen J. Traub and Lewis S. Nelson 12. Biochemical and Metabolic Principles, Kurt C. Kleinschmidt and Kathleen A. Delaney 13. Neurotraansmitters and Neuromodulators, Steven C. Curry, Kirk C. Mills, Anne-Michalle Ruha, and Ayrn D. O'Connor 14. Withdrawal Principles, Richard J. Hamilton Section 2: Pathophysiologic Basis: Organ Systems 15. Thermoregulatory Principles, Susi U. Vassallo and Kathleen A. Delaney 16. Fluid, Electrolyte, and Acid-Based Principles, Alan N. Charney and Robert S. Hoffman 17. Psychiatric Principles, Kishor Malavade and Mark R. Serper 18. Neurologic Principles, Rama B. Rao 19. Ophthalmic Principles, Adhi Sharma 20. Otolaryngologic Principles, William K. Chiang 21. Respiratory Principles, Andrew Stolbach and Robert S. Hoffman 22. Electrophysiologic and Electrocardiographic Principles, Cathleen Clancy 23. Hemodynamic Principles, Robert A. Hessler 24. Hematologic Principles, Marco L.A. Sivilotti 25. Gastrointestinal Principles, Richard J. Church and Kavita M. Babu 26. Hepatic Principles, Kathleen A. Delaney 27. Renal Principles, Donald A. Feinfeld and Nikolas B. Harbord 28. Genitourinary Principles, Jason Chu 29. Dermatologic Principles, Neal A. Lewin and Lewis S. Nelson Section 3: Special Populations 30. Reproductive and Perinatal Principles, Jeffrey S. Fine 31. Pediatric Principles, Jeffrey S. Fine 32. Geriatric Principles, Judith C. Ahronheim and Mary Ann Howland 33. Postmortem Toxicology, Rama B. Rao and Mark Flomenbaum SC1. Organ Procurement from Poisoned Patients, Rama B. Rao PART C: THE CLINICAL BASIS OF MEDICAL TOXICOLOGY Section 1: Case Studies A. Analgesics and Antiinflammatory Medications 34. Acetaminophen, Robert G. Hendrickson A4. N-Acetylcysteine, Mary Ann Howland and Robert G. Hendrickson 35. Salicylates, Neal E. Flomenbaum A5. Sodium Bicarbonate, Paul M. Wax 36. Nonsteroidal Antiinflammatory Drugs, William J. Holubek 37. Colchicine, Podophyllin, and the Vinca Alkoloids, Joshua G. Schier SC2. Intrathecal Administration of Xenobiotics, Rama B. Rao 38. Opioids, Lewis S. Nelson and Dean Olsen A6. Opioid Antagonists, Mary Ann Howland and Lewis Nelson B. Foods, Dietary and Nutritional Agents 39. Dieting Agents and Regimens, Jeanna M. Marraffa 40. Iron, Jeanmarie Perrone A7. Deferoxamine, Mary Ann Howland 41. Vitamins, Beth Y. Ginsburg 42. Essential Oils, S. Eliza Halcomb 43. Herbal Preparations, Oliver L. Hung 44. Athletic Performance Enhancers, Susi U. Vassallo 45. Food Poisoning, Michael G. Tunik 46. Botulism, Howard L. Geyer A8. Botulinum Antitoxin, Lewis R. Goldfarb and Howard L. Geyer C. Pharmaceuticals 47. Anticonvulsants, Suzanne Doyon A9. L-Carnitine, Mary Ann Howland 48. Antidiabetics and Hypoglycemics, George M. Bosse A10. Dextrose, Larissa I. Velez and Kathleen A. Delaney A11. Octreotide, Mary Ann Howland 49. Thyroid and Antithyroid Medications, Nicole C. Bouchard 50. Antihistamines and Decongestants, Anthony J. Tomassoni and Richard S. Weisman A12. Physostigmine Salicylate, Mary Ann Howland 51. Antimigraine Medications, Jason Chu 52. Antineoplastics Overview, Richard Y. Wang 53. Antineoplastics: Methotrexate, Richard Y. Wang A13. Leucovorin (Folinic Acid) and Folic Acid, Mary Ann Howland A14. Glucarpidase, (Carboxypeptidas G2), Silas W. Smith SC3. Extravasation of Xenobotics, Richard Y. Wang 54. Miscellaneous Antineoplastics, Richard Y. Wang 55. Pharmaceutical Additives, Sean P. Nordt and Lisa E. Vivero D. Antimicrobials 56. Antibacterials, Antifungals, and Antivirals, Christine M. Stork 57. Antituberculous Medications, Christina H. Hernon and Edward W. Boyer 58. Antimalarials, J. Dave Barry E. Cardiopulmonary Medications 59. Anticoagulants, Mark Su A16. Vitamin K, Mary Ann Howland A17. Protamine, Mary Ann Howland 60. Calcium Channel Blockers, Francis DeRoos A18. Insulin-Eyglycemia Therapy, William Kerns II 61. B-Adrenergic Antagonists, Jeffrey R. Brubacher A19. Glucagon, Mary Ann Howland 62. Other Antihypertensives, Francis DeRoos 63. Antidysrhythmics, Lewis S. Nelson and Neal A. Lewin 64. Cardioactive Steroids, Jason B. Hack A20. Digoxin-Specific Antibody Fragments, Mary Ann Howland 65. Methylxanthines and Selective B2 Adrenergic Agonists, Robert J. Hoffman F. Anesthetics and Related Medications 66. Local Anesthetics, David R. Schwartz and Brian Kaufman A21. Intravenous Fat Emulsions, Todd Bania 67. Inhalational Anesthetics, Brian Kaufman and Martin Griffel 68. Neuromuscular Blockers, Kenneth M. Sutin A22. Dantrolene Sodium, Kenneth M. Sutin G. Psychotropic Medications 69. Antipsychotics, David Juurlink 70. Lithium, Howard A. Greller 71. Monoamine Oxidase Inhibitors, Alex F. Manini 72. Serotonin Reuptake Inhibitors and Atypical Antidepressants, Christine M. Stork 73. Cyclic Antidepressants, Erica L. Liebelt 74. Sedative-Hynotics, David C. Lee and Kathy Ferguson A23. Flumazenil, Mary Ann Howland H. Substances of Abuse 75. Amphetamines, William K. Chiang 76. Cocaine, Jane M. Prosser and Robert S. Hoffman SC4. Internal Concealment of Xenobiotics, Jane M. Prosser A24. Benzodiazepines, Robert S. Hoffman, Lewis S. Nelson, and Mary Ann Howland 77. Ethanol, Luke Yip A25. Thiamine Hydrochloride, Robert S. Hoffman 78. Ethanol Withdrawal, Jeffrey Gold and Lewis S. Nelson 79. Disulfiram and Disulfiram-Like Reactions, Edwin K. Kuffner 80. Y-Hydroxybutyric Acid, Brenna M. Farmer 81. Inhalants, Heather Long 82. Hallucinogens, Kavita M. Babu 83. Cannabinoids, Michael A. McGuigan 84. Nicotine, Sari Soghoian 85. Phencyclidine and Ketamine, Ruben Olmedo 86. Aluminum, Brenna M. Farmer I. Metals 87. Antimony, Asim F. Tarabar 88. Arsenic, Stephen W. Munday and Marsha Ford A26. Dimercaprol (British Anti-Lewisite or Bal), Mary Ann Howland 89. Bismuth, Rama B. Rao 90. Cadmium, Stephen J. Traub and Robert s. Hoffman 91. Chromium, Steven B. Bird 92. Cobalt, Gar Ming Chan 93. Copper, Lewis S. Nelson 94. Lead, Fred M. Henretig A27. Succimer (2,3-Dimercaptosuccinic Acid), Mary Ann Howland A28. Edetate Calcium Disodium (CaNa2EDTA), Mary Ann Howland 95. Manganese, Sari Soghoian 96. Mercury, Young-Jin Sue 97. Nickel, John Curtis and David A. Haggerty 98. Selenium, Diane P. Calello 99. Silver, Melisa W. Lai Becker and Michele Burns Ewald 100. Thallium, Maria Mercurio and Robert S. Hoffman A29. Prussian Blue, Robert S. Hoffman 101. Zinc, Nima Majlesi J. Household Products 102. Antiseptics, Disinfectants, and Sterilants, Paul M. Wax 103. Camphor and Moth Repellents, Edwin K. Kuffner 104. Caustics, Jessica A. Fulton 105. Hydrofluoric Acid and Fluorides, Mark Su A30. Calcium, Mary Ann Howland 106. Hydrocarbons, David D. Gummin 107. Toxic Alcohols, Sage W. Wiener SC5. Diethylene Glycol, Joshua G. Schier A31. Fomepizole, Mary Ann Howland A32. Ethanol, Mary Ann Howland K. Pesticides 108. Pesticides: An Overview with a Focus on Principles and Rodenticides, Neal F. Flomenbaum 109. Barium, Andrew Dawson 110. Sodium Monofluoroacetate and Fluroacetamide, Fermin Barrueeto Jr. 111. Phosphorus, Michael Beuhler 112. Strychnine, Yiu-Cheung Chan 113. Insecticides: Organic Phosphorus Compounds and Carbamates, Michael Eddleston and Richard F. Clark A33. Pralidoxmine, Mary Ann Howland A34. Atropine, Mary Ann Howland 114. Insecticides: Organic Chlorines, Pyrethrins/Pyrethroids, and Insect Repellents, Michael G. Holland 115. Herbicides, Darren M. Roberts 116. Methyl Bromide and Other Fumigants, Keith K. Burkhart L. Natural Toxins and Envenomations 117. Mushrooms, Lewis R. Goldfrank 118. Plants, Mary Palmer and Joseph M. Betz 119. Arthropods, In-Hei Hahn A35. Antivenom (Scorpion and Spider), Richard F. Clark 120. Marine Envenomations, D. Eric Brush 121. Snakes and Other Reptiles, Bradley D. Riley, Anthony F. Pizon, and Anne-Michelle Ruha A36. Antivenom (Crotaline and Elapid), Anthony F. Pizon, Bradley D. Riley, and Anne-Michelle Ruha M. Occupational and Environmental Toxins 122. Industrial Poisoning: Information and Control, Peter H. Wald 123. Nanotoxicology, Silas W. Smith 124. Simple Asphyxiants and Pulmonary Irritants, Lewis Nelson and Oladapo Obujebe 125. Carbon Monoxide, Christian Tomaszewski A37. Hyperbaric Oxygen, Stephen R. Thom 126. Cyanide Andhydrogen Sulfide, Christopher P. Hostege, Gary E. Isom, and Mark A. Kirk A38. Sodium and Amyl Nitrites, Mary Ann Howland A39. Sodium Thiosulfate, Mary Ann Howland A40. Hydroxocobalamin, Mary Ann Howland 127. Methemoglobin Inducers, Dennis P. Price A41. Methylene Blue, Mary Ann Howland 128. Smoke Inhalation, Nathan Charlton and Mark A. Kirk N. Disaster Preparedness 129. Risk Assessment and Risk Communications, Charles McKay, Jr. 130. Hazmat Incident Response, Bradley Kaufman 131. Chemical Weapons, Jeffrey R. Suchard 132. Biological Weapons, Jeffrey R. Suchard 133. Radiation, Joseph Rella A42. Potassium Iodide, Joseph Rella A43. Pentetic Acid (Dtpa) or Pentetate (Zinc or Calcium) Trisodium, Joseph Rella Section 2: Poison Centers and Epidemiology 134. Poison Prevention and Education, Lauren Schwartz 135. Poison Centers and Poison Epidemiology, Robert S. Hoffman 136. International Perspectives on Toxicology, Michael Eddleston 137. Principles of Epidemiology and Research Design, Kevin C. Osterhoudt 138. Adverse Drug Events and Postmarketing Surveillance, Louis R., Cantilena 139. Medication Safety and Adverse Drug Events, Brenna M. Farmer 140. Risk Management and Legal Principles, Barbara M. Kirrane and Dainius A. Drukteinis Index

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Lewis S. Nelson, MD, FACEP, FACMT Director, Medical Toxicology Fellowship Program; Associate Director, New York City Poison Center; Attending Physician, Department of Emergency Medicine, Bellevue Hospital Center and New York University Medical Center; Assistant Professor of Emergency Medicine, New York University School of Medicine, New York, New York. Neal A. Lewin, MD, FACP, FACEP, FACMT Director, Didactic Education, Attending Physician, Department of Emergency Medicine, Bellevue Hospital Center and New York University Medical Center; Clinical Associate Professor of Emergency Medicine and Medicine (Clinical Pharmacology), New York University School of Medicine; Consultant, New York City Poison Center, New York, New York. Mary Ann Howland, PharmD, DABAT, FAACT Clinical Professor of Pharmacy, St. John’s University College of Pharmacy; Consultant, Department of Emergency Medicine, Bellevue Hospital Center and New York University Medical Center; Senior Consultant in Residence, New York City Poison Center, New York, New York. Robert S. Hoffman, MD, FAACT, FACMT Director, New York City Poison Center; Attending Physician, Department of Emergency Medicine, Bellevue Hospital Center and New York University Medical Center; Associate Professor, Emergency Medicine and Medicine (Clinical Pharmacology), New York University School of Medicine, New York, New York. Lewis R. Goldfrank, MD, FACEP, FAAEM, FAACT, FACMT, FACP Professor and Chair, Department of Emergency Medicine, New York University School of Medicine; Director, Emergency Medicine, Bellevue Hospital Center and New York University Medical Center; Medical Director, New York City Poison Center, New York, New York. Neal E. Flomenbaum, MD, FACP, FACEP Emergency Physician-in-Chief, New York Presbyterian Hospital; Professor of Clinical Medicine, Weill Medical College, Cornell University; Consultant, New York City Poison Center, New York, New York.

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