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Author:   Joyce W. Lustbader ,  David Puett ,  Raymond W. Ruddon ,  Function Symposium on Glycoprotein Hormones: Structure
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   1994 ed.
Dimensions:   Width: 16.50cm , Height: 2.50cm , Length: 24.80cm
Weight:   0.760kg
ISBN:  

9780387941653

ISBN 10:   0387941657
Pages:   381
Publication Date:   13 May 1994
Audience:   General/trade ,  General
Format:   Hardback
Publisher's Status:   Active
Availability:   Temporarily unavailable  
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Table of Contents

I. Reflections Past and Present.- 1. Reflections on Purifying Gonadotropins in the 1960s.- 2. Where to from Here?.- 3. Remembrance of Things Foregone.- II. Regulation of Gene Expression.- 4. Endocrine Regulation of Glycoprotein Hormone Alpha Subunit Gene Expression in Transgenic Mice.- 5. Coordinate Regulation of the Gonadotropin Subunit Genes in Pituitary and Placenta.- 6. Role of Helix-Loop-Helix Proteins in Gonadotropin Gene Expression.- 7. Cyclic AMP-Mediated Hormonal Regulation of Gene Transcription.- 8. Regulation and Expression of Thyroid Stimulating Hormone.- III. Hormonal Protein Structure/Function.- 9. Human Chorionic Gonadotropin: Progress in Determining Its Tertiary Structure.- 10. Receptor Binding Regions of hLH and hCG?-Subunit: Structural and Functional Properties.- 11. Evidence for Altered Splicing in Two Members of the Chorionic Gonadotropin ? Gene Cluster.- 12. Delineation of Subunit and Receptor Contact Sites by Site-Directed Mutagenesis of hCG?.- IV. Protein Processing and Posttranslational Events.- 13. Folding of the ?-Subunit of hCG and Its Role in Assembly of the ?-? Heterodimer.- 14. Structure and Function of the Gonadotropin Free ? Molecule of Pregnancy.- 15. Glycosylation and Glycoprotein Hormone Function.- V. Receptor Structure/Function.- 16. Structure and Regulated Expression of the TSH Receptor Gene: Differences and Similarities to Gonadotropin Receptors.- 17. Studies on the Structure and Function of Gonadotropins.- 18. Hormone Binding and Activation of the LH/CG Receptor.- VI. Clinical Implications.- 19. Use of the Free Alpha Subunit (FAS) of Glycoprotein Secreting Hormones as a Surrogate Marker of GnRH Secretion in the Human.- 20. Free hCG? and Nongonadal Neoplasms.- 21. New Clinical Applications of hCG Assays.- 22. ?-CoreFragment: Structure, Production, Metabolism, and Clinical Utility.- 23. Human Pituitary Chorionic Gonadotropin Is Produced, Circulated, and Excreted in Multiple Isoforms.- 24. Thyrotropin Abnormalities in Central Hypothyroidism.- Appendix: Poster Presentations.- Author Index.

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