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OverviewBoth metabotropic and ionotropic glutamate receptors present attractive “druggable” targets in treating disorders of the central nervous system. There has been a dramatic shift in the focus of glutamate-based therapies away from neurologic disorders such as stroke and traumatic brain injury to the treatment of psychiatric disorders. This “Milestones in Drug Therapy” volume offers a unique, contemporary overview of preclinical and clinical evidence that modulating glutamatergic tone is an effective means of treating psychiatric disorders ranging from depression and anxiety to schizophrenia and drug abuse. The ability to treat diseases such as depression and schizophrenia through multiple, glutamate-based mechanisms offers a unique therapeutic opportunity, as described in this book. Full Product DetailsAuthor: Phil SkolnickPublisher: Birkhauser Verlag AG Imprint: Birkhauser Verlag AG Dimensions: Width: 15.50cm , Height: 1.80cm , Length: 23.50cm Weight: 0.494kg ISBN: 9783034602402ISBN 10: 3034602405 Pages: 178 Publication Date: 09 September 2010 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: In Print ![]() This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsN-Methyl-d-Aspartate (NMDA) Antagonists for the Treatment of Depression.- Ionic Glutamate Modulators in Depression (Zinc, Magnesium).- Positive Allosteric Modulation of AMPA Receptors: A Novel Potential Antidepressant Therapy.- Glutamatergic Modulators for the Treatment of Major Depressive Disorder: Metabotropic Glutamate Receptors.- Positive Modulation of AMPA Receptors as a Broad-Spectrum Strategy for Treating Neuropsychiatric Disorders.- Activation of Group II Metabotropic Glutamate Receptors (mGluR2 and mGluR3) as a Novel Approach for Treatment of Schizophrenia.- mGluR1 Negative Allosteric Modulators: An Alternative Metabotropic Approach for the Treatment of Schizophrenia.- Metabotropic Glutamate Receptors as Targets for the Treatment of Drug and Alcohol Dependence.- Metabotropic Approaches to Anxiety.ReviewsFrom the reviews: This book summarizes the translational research in the development of glutamate-based approaches to treat psychiatric disorders. Written and edited by an international group of researchers, it is an important addition to the psychiatric literature. ! The intended audience includes psychiatric researchers and psychiatrists. Neuroscientists interested in the treatment of patients with psychiatric disorders also would benefit from reading this book. ! The index is quite helpful. ! presents a unique and novel approach that is desperately needed in the treatment of these difficult disorders. (Michael Joel Schrift, Doody's Review Service, February, 2011) From the reviews: This book summarizes the translational research in the development of glutamate-based approaches to treat psychiatric disorders. Written and edited by an international group of researchers, it is an important addition to the psychiatric literature. ... The intended audience includes psychiatric researchers and psychiatrists. Neuroscientists interested in the treatment of patients with psychiatric disorders also would benefit from reading this book. ... The index is quite helpful. ... presents a unique and novel approach that is desperately needed in the treatment of these difficult disorders. (Michael Joel Schrift, Doody's Review Service, February, 2011) From the reviews: This book summarizes the translational research in the development of glutamate-based approaches to treat psychiatric disorders. Written and edited by an international group of researchers, it is an important addition to the psychiatric literature. ... The intended audience includes psychiatric researchers and psychiatrists. Neuroscientists interested in the treatment of patients with psychiatric disorders also would benefit from reading this book. ... The index is quite helpful. ... presents a unique and novel approach that is desperately needed in the treatment of these difficult disorders. (Michael Joel Schrift, Doody's Review Service, February, 2011) Author InformationTab Content 6Author Website:Countries AvailableAll regions |