Overview

This monograph brings the reader up to date on the basic therapeutic mechanism of glucocorticoid action in the treatment of various lymphoproliferative diseases, most notably in acute lymphoblastic leukemias. As a target protein, the structure and function of both the intracellular and plasma membrane-associated glucocorticoid receptors are reviewed. The various functional domains of the glucocorticoid receptor interaction with a variety of heat shock proteins, transcription factors and specific DNA sequences and how this leads to biological response are addressed. The book aims at leading not only to a better understanding of how glucocorticoid hormones impart their therapeutic effect, but also to the eventual development of efficient diagnostic tools for the identification of hormone-responsive leukemic patients.

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9783540592198

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