Overview
Genomics-Guided Natural Products Discovery, Volume 717 focuses on how the genomics revolution has catalyzed a resurgence of interest in natural products research. With the explosion of new sequencing data to analyze, “genome-mining” tools have grown in sophistication. Hence, this volume captures the utility of these tools, serving as a how-to guide to lower the entry barrier for newcomers. Topics covered in this new release include Merging RODEO with genomic enzymology workflows to guide RiPP discovery, Exploring Ribosomally Synthesized and Post-translationally Modified Peptides through SPECO-Based Genome Mining, Genome Mining for Natural Products Made by Multinuclear Iron-dependent Oxidation Enzymes (MNIOs), and much more. Additional sections explore Genome-based discovery of polyketides generated by trans-acyltransferase polyketide synthases, Global genome mining in fungi using FunBGCe, Plant genome mining of burpitides from fused precursor peptides, Determining biosynthetic gene cluster boundaries thru comparative bioinformatics, Genome mining for bacterial terpenoids, Bioinformatics guided synthesis of natural product cyclic peptides, Overview of Genome Mining Strategies for Natural Products Discovery, and much more.
Full Product Details
Author: Douglas A Mitchell (Department of Chemistry, University of Illinois, USA)
Publisher: Elsevier Science Publishing Co Inc
Imprint: Academic Press Inc
Weight: 0.450kg
ISBN: 9780443345272
ISBN 10: 0443345279
Pages: 470
Publication Date: 01 July 2025
Audience:
Professional and scholarly
,
Professional & Vocational
Format: Hardback
Publisher's Status: Active
Availability: In Print
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.
Author Information
Doug Mitchell holds the Warren Professorship in the Department of Biochemistry at Vanderbilt University and serves as Director of the Vanderbilt Institute for Chemical Biology. He also holds an appointment in the Department of Chemistry. Mitchell received a BS in Chemistry from Carnegie Mellon University, PhD in Chemistry from UC Berkeley (Marletta), and completed postdoctoral work at UC San Diego (Dixon). Mitchell joined the Department of Chemistry at the University of Illinois at Urbana-Champaign faculty in 2009 with promotion to Associate Professor in 2015 and Professor in 2018. In 2019, Mitchell co-founded Lassogen, Inc. (San Diego), which is developing lasso peptides as a new modality for treating cancer. In 2024, he moved to his current position at Vanderbilt. Mitchell’s research centers on the chemical biology of natural product biosynthesis, and derives insights from big data genomics, mechanistic enzymology, and synthetic biology. Edit
