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Full Product Details

Author:   James R. Lupski ,  Pawel T. Stankiewicz
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2006 ed.
Dimensions:   Width: 17.80cm , Height: 2.50cm , Length: 25.40cm
Weight:   1.136kg
ISBN:  

9781588295590

ISBN 10:   1588295591
Pages:   426
Publication Date:   15 April 2006
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

The CMT1A Duplication.- Genomic Structure.- Alu Elements.- The Impact of LINE-1 Retro transposition on the Human Genome.- Ancient Transposable Elements, Processed Pseudogenes, and Endogenous Retroviruses.- Segmental Duplications.- Non-B DNA and Chromosomal Rearrangements.- Genetic Basis of Olfactory Deficits.- Genomic Organization and Function of Human Centromeres.- Genome Evolution.- Primate Chromosome Evolution.- Genome Plasticity in Evolution.- Genomic Rearrangements and Disease Traits.- The CMT1A Duplication and HNPP Deletion.- Smith-Magenis Syndrome Deletion, Reciprocal Duplication dup(17)(p11.2p11.2), and Other Proximal 17p Rearrangements.- Chromosome 22q11.2 Rearrangement Disorders.- Neurofibromatosis 1.- Williams-Beuren Syndrome.- Sotos Syndrome.- X Chromosome Rearrangements.- Pelizaeus–Merzbacher Disease and Spastic Paraplegia Type 2.- Y-Chromosomal Rearrangements and Azoospermia.- Inversion Chromosomes.- Monosomy 1p36 As a Model for the Molecular Basis of Terminal Deletions.- inv dup(15) and inv dup(22).- Mechanisms Underlying Neoplasia-Associated Genomic Rearrangements.- Functional Aspects of Genome Structure.- Recombination Hotspots in Nonallelic Homologous Recombination.- Position Effects.- Genomic Disorders: Modeling And Assays.- Chromosome-Engineered Mouse Models.- Array-CGH for the Analysis of Constitutional Genomic Rearrangements.

Reviews

...an attempt to bridge the gap between genomic technology and clinical applications of genomic knowledge. -Doody's Book Review, Weighted Numerical Score: 84 - 3 stars ...a unique contribution in a very specialized field. -Doody's Book Review, Weighted Numerical Score: 84 - 3 stars

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