Overview

This textbook illustrates the importance and significance of molecular genetic testing in reproductive disorders. The present book covers the genetic testing in various reproductive system anomalies, including disorders of sexual development, male infertility (Y deletions, autosomal mutations, sperm DNA fragmentation), female infertility (PCOS and POF), mitochondrial DNA testing for oocyte quality, recurrent pregnancy loss, pre-term birth, endometrial receptivity, prenatal genetic screening, reproductive carrier screening, preimplantation genetic screening, endometrial cancer, cervical cancer and other related reproductive health disorders. Microbiome testing and its contribution to genetic testing in reproductive medicine are also discussed. Genetic testing in some of these has already come into practice, genetic testing for others is established but not clinically practiced, and genetic testing for others is yet in infancy as there is only limited data available. For the disorderswhere sufficient genetic data to undertake genetic testing is not available, we have tried to put together the evidence for proposing such tests in the near future. Apart from this, the book also covers ethical, moral and technical challenges in genetic testing in reproductive medicine. The book aims to set up a standard with regard to genetic testing in the reproductive medicine field, encourage further data generation, and provide food for thought in the areas of lacunae. The book serves graduate students, researchers, clinicians, professors, and patients in the field of reproductive medicine.​

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9789819970278

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Dr. Rajender Singh is a Senior Principal Scientist and Professor of Biology at the Central Drug Research Institute (CDRI), Lucknow, India. He has been working as a scientist in this institute for the last 16 years. His research interests lie in genetics and genomics of male reproduction and infertility with specific emphasis on sperm RNAs and epigenome. Dr. Singh has published more than 150 research articles, 36 book chapters and 3 books in the area of reproductive biology. Dr. Singh is serving as an associate editor for Reproductive Biology and Endocrinology, Reproductive Health and Andrologia journals, and as Andrology Specialty Chief Editor for Frontiers in Reproductive Health journal. His work has been recognized by a number of prestigious scientific bodies in the form of Haryana Yuva Vigyan Ratna Award (2018), the INDO US Post-doctoral Research Fellowship at the University of Alabama at Birmingham (2017), the Innovative Young Biotechnologist Award from the Department of Biotechnology (2015), the Young Scientist Award from the Council of Scientific and Industrial Research (2014), the Young Scientist Award from the Indian Science Congress Association (2012), the Young Scientist Award from the Indian National Scientific Academy (2011) and the Young Scientist Award from the Indian Society of Human Genetics (2006). He is a member of the Indian Society for the study of Reproduction and Fertility (ISSRF), Indian Fertility Society (IFS), the Indian Society of Human Genetics (ISHG). ​

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