Overview

Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens. This book brings together contributions from experts from multiple disciplines who discuss: How epidemiological cohort studies can better integrate physiological (mechanistic) measures;How best to characterise subjects' vulnerability versus resilience by moving beyond single genetic polymorphisms;How gene hunters can benefit from recruiting samples selected for known exposures;How environmental pathogens can be used as tools for gene hunting;How to deal with potential spurious (statistical) interactions, andHow genes can help explain fundamental demographic properties of disorders (e.g. sex distribution, age effects).

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9781281840486

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