Overview

This book is a comprehensive resource on possible DNA damages in sperm, the relation to male infertility, and possible transgenerational heritable effects. There are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate during spermatogenesis, or it can originate during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The new edition presents a thorough update of the state of science for genetic damage in human spermatozoa. It focuses on basic or clinical aspects related to genetic damage in human spermatozoa, including when and why sperm DNA fragmentation (sDF) should be tested in clinical practice; which is the best method to reveal sDF, and whether novel tools for sperm selection will advance current results. Chapters also cover the state of art of genetic causes of male infertility, the advancing promised by the next-generation sequencing (NGS), as well as the the novelties coming from the field of epigenetics, from the concept of epigenetic developmental plasticity, to the potential diagnostic and prognostic role of sperm epigenome evaluation in the field of male infertility and assisted reproduction.

Full Product Details

Author:   Monica Muratori, Ph.D. ,  Ettore Caroppo
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
Edition:   Third Edition 2026
ISBN:  

9783032183750

ISBN 10:   3032183758
Pages:   204
Publication Date:   20 April 2026
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Forthcoming
Availability:   Not yet available  
This item is yet to be released. You can pre-order this item and we will dispatch it to you upon its release.

Table of Contents

Evaluating sperm DNA damage when and why it adds to the management of the infertile man.- Evaluating sperm DNA damage when and why it does not add to the evaluation of male factor infertility.- Comparing methods for sperm DNA fragmentation detection.- Sperm selection procedures in cases of high sperm DNA fragmentation index.-Environmental lifestyle and other factors affecting sperm DNA integrity.- Effects of cytotoxic therapies on the sperm genome and epigenome.- Gene defects and sperm abnormalities.- Genetic evaluation of the infertile man indications to whole exome sequencing.- Epigenetic developmental plasticity effect on fertility and on offsprings health.- The sperm epigenome implications for medically assisted reproduction.- Methods for investigating the sperm epigenome.- Sperm non coding RNAS how to test when and to whom.

Reviews

Author Information

Monica Muratori, PhD, is an associate professor of Applied Technical and Medical Sciences in the Department of Experimental and Clinical Biomedical Sciences at the University of Florence in Italy. She started to work in sperm biology in the late 90s by mainly studying sperm DNA damage. She serves as an Associate Editor for Andrology. Ettore Caroppo, MD, is a physician at the Andrology Outpatients Clinic, ASL Bari, PTA ""F Jaia"", Conversano (Ba), in Italy. He serves as an Associate Editor for Human Reproduction and Andrology (Wiley), and Editorial Board Member for Fertility and Sterility and Asian Journal of Andrology. He is also Academician of the European Academy of Andrology.

Tab Content 6

Author Website:  

Countries Available

All regions