Overview

Edward B. Lewis' science is the bridge linking experimental genetics as conducted in the first half of the 20th century, and the powerful molecular genetic approaches that revolutionized the field in its last quarter. His Nobel Prize winning studies founded the field of developmental genetics and laid the groundwork for our current understanding of the universal, evolutionarily conserved strategies controlling animal development. A lesser-known aspect of Lewis' canon is the pioneering studies he carried out on ionizing radiation and human cancer. In doing so, he was propelled into a public storm over nuclear weapons testing policy. For the first time Lewis' key publications in the fields of genetics, developmental biology, radiation and cancer are compiled within one volume. Howard Lipshitz, a close colleague of Lewis for 20 years, provides invaluable commentaries on the papers placing them in their scientific and historical context and, throughout, giving insight into Lewis' approach to science and the motivations that drove Lewis' choice of subject matter. This book will be invaluable to a wide audience of professionals in the life and biomedical sciences; including geneticists, developmental biologists, molecular biologists, radiation biologists and cancer researchers. It provides source material for advanced undergraduate and graduate level courses in genetics, developmental biology, radiation and cancer. In addition, historians of science will find it to be a valuable resource both because it contains original research publications and because of the illuminating commentary.

Full Product Details

Author:   Howard D. Lipshitz
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2004 ed.
Dimensions:   Width: 15.50cm , Height: 4.10cm , Length: 23.50cm
Weight:   1.120kg
ISBN:  

9781402075919

ISBN 10:   140207591
Pages:   557
Publication Date:   31 January 2004
Audience:   General/trade ,  Professional and scholarly ,  College/higher education ,  General ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

E. B. Lewis and His Science.- Lewis and the Nature of the Gene.- Star-recessive, a spontaneous mutation in Drosophila melanogaster. Proceedings of the Minnesota Academy of Science 7:23–26.- Another case of unequal crossing over in Drosophila melanogaster. Proceedings of the National Academy of Sciences USA 27:31–34.- The relation of repeats to position effect in Drosophila melanogaster. Genetics, 30:1377–166.- The pseudoallelism of white and apricot in Drosophila melanogaster. Proceedings of the National Academy of Sciences USA 38:953–961.- Pseudoallelism and gene evolution. Cold Spring Harbor Symposia on Quantitative Biology, 16:159–174.- The theory and application of a new method of detecting chromosomal rearrangements in Drosophila melanogaster. American Naturalist 88:225–239.- Some aspects of position pseudoallelism. American Naturalist 89:73–89.- Genes and gene complexes. Heritage from Mendel, pp. 17–47.- Lewis and the Genetic Control of Development.- Genes and developmental pathways. American Zoologist, 3:33–56.- A gene complex controlling segmentation in Drosophila. Nature, 276:565–570.- Genetic control of body segment differentiation in Drosophila.- Control of body segment differentiation in Drosophila by the bithorax gene complex.- Regulation of the genes of the bithorax complex in Drosophila. Cold Spring Harbor Symposia on Quantitative Biology, 50:155–164.- Lewis and the Molecular Control of Development.- Molecular genetics of the bithorax complex in Drosophila melanogaster. Science, 221:23–29.- The abdominal region of the bithorax complex. Cell, 43:81–96.- Transabdominal, a dominant mutant of the bithorax complex, produces sexually dimorphic segmental transformation of Drosophila. Genes and Development, 1:111–123.- Molecular basisof Transabdominal—a novel sexually dimorphic mutant of the bithorax complex of Drosophila. Proceedings of the National Academy of Sciences USA 90:1566–1570.- Sequence analysis of the cis-regulatory regions of the bithorax complex of Drosophila. Proceedings of the National Academy of Sciences USA 92:8403–8407.- Splits in fruitfuly Hox gene complexes. Nature, 380:116.- Evolution of the homeobox complex in the Diptera. Current Biology, 13:R587–R588.- Lewis and the Somatic Effects of Ionizing Radiation.- Leukemia and ionizing radiation. Science, 125:965&3x2013;972.- Thyroid radiation doses from fallout. Proceedings of the National Academy of Sciences 45:894–897.- Leukemia, multiple myeloma, and aplastic anemia in American radiologists. Science, 142:1492–1494.- Ionizing radiation and tumor production. In: Genetic Concepts and Neoplasia, Williams and Wilkins Co, pp. 57–73.- Letters: Leukemia, radiation, and hyperthyroidism. Science, 174:454.- Analysis of lung tumor mortality in the Batelle Beagle Lifespan experiment.- Ionizing radiation, cancer induction and radioactive fallout.- Homeosis: the first 100 years. Trends in Genetics, 10:341–343.- Remembering Sturtevant. Genetics, 141:1227–1230.- C. B. Bridges’ repeat hypothesis and the nature of the gene. Genetics: in press.- Autobiographical sketch.- The bithorax complex: the first fifty years. Les Prix Nobel, 1995. Almquist & Wiksell International: Stockholm, Sweden, pp. 233–260.- Curriculum vitae of E. B. Lewis.- References.

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