Overview

Gene transfer technology is a powerful tool for increasing our understandingof brain functions. It is also the basis of gene therapy, which is now technically possible for the correction of many human diseases, including several disorders of the nervous (and muscular) system such as Alzheimer's disease, Parkinson's disease, and dystrophy. This volume,which contains the proceedings of a symposium of the Fondation Ipsen, provides a unique view of the state of the art on different transgenes, vectors, target cells, and clinical applications related to the nervous system.

Full Product Details

Author:   Fred H. Gage
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1992
Dimensions:   Width: 17.00cm , Height: 1.20cm , Length: 24.20cm
Weight:   0.405kg
ISBN:  

9783642848445

ISBN 10:   3642848443
Pages:   211
Publication Date:   15 December 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Somatic Cell Gene Therapy.- Delivery of Nerve Growth Factor Within the Rat Brain Using Genetically Modified Cells.- A Potential Approach to Gene Therapy of Cancer.- Phenotypic Plasticity and Neural Grafting.- The Sympathoadrenal Progenitor of the Neural Crest: Basic Biology and Therapeutic Potential.- Lineage, Migration, and Phenotype in Avian Optic Tectum: Analysis with Recombinant Retroviral Vectors.- Immortal Mammalian Neuronal Stem Cells Differentiate after Implantation into the Developing Brain.- Establishment of Clonal Cell Lines for the Study of Neural Function and Dysfunction.- Resistance of SOD-Transgenic Mice to Oxidative Stress.- Gene Transfer into the Nervous System using Recombinant Herpes Virus Vectors.- Development of Herpes Simplex Virus as a Gene Transfer Vector for the Central Nervous System.- Dystrophin mRNA Processing in the Canine Homologue of Duchenne Muscular Dystrophy: An Authentic Model for Gene Therapy.- Gene Transfer of a Murine Dystophin Minigene Construct.- Gene Therapy in Animal Models of Neurological Disorders.- Neurotrophins and their Receptors.- Regulation of the Human Neurofilament Light and Heavy Genes in Transgenic Mice.

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