Overview

This book addresses the latest advances in viral and non-viral vectors, novel targets and methods for the treatment of autoimmune and inflammatory disease with a main focus in pre-clinical testing with up to date clinical trials. The first section of the book deals with current research approaches for treating rheumatoid arthritis, osteoarthritis, diabetes, Crohn's disease, multiple sclerosis, Sjogrens syndrome, cystic fibrosis, myositis and lupus. The second section is devoted to cell delivery and vector development including plasmids, regulated promoters, adenovirus gutted vectors and adeno-associated vectors. All chapters are summarised by leaders in these fields. A must read for post graduate students, clinical and non-clinical researchers in the disciplines of immunology, molecular medicine, pharmacology, gene and cell-mediated therapy.

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9781283074575

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<p>From the reviews: <p> This monograph contains new and valuable information regarding relevant topics ranging from disease entities to vectors and engineered cells. The authors, all of them international experts, take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long term genetic interventions. The present volume is of an exceptional value for clinicians and scientists interested in introducing gene therapy into clinical use. (Magdalena Moisei, Romanian Journal of Biochemistry, Vol. 47 (2), 2010)

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